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Abstract

Theophylline is an important drug for treatment of canine chronic bronchitis and bradyarrhythmias, but new products require validation since pharmacokinetics in dogs can vary by formulation. A new, 503B outsourcing facility-produced theophylline product (OFT) is available for veterinary use....

Author(s)
Reinhart, J. M.; Oliveira, G. A. R. de; Forsythe, L.; Li, Z.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2022, 17, 1,
Abstract

Itraconazole (ITZ) is an important drug in the treatment of superficial and deep mycoses in dogs. Its primary metabolite is hydroxy-itraconazole, which has antifungal activity similar to the parent compound. The purpose of this study was to identify the cytochrome P450 enzyme (CYP) isoform(s)...

Author(s)
Tonero, M. E.; Li Zhong; Reinhart, J. M.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2022, 45, 3, pp 255-264
Abstract

Theophylline is used in canine medicine for the management of chronic bronchitis and bradyarrhythmias, yet no species-validated commercial products are available. This study reports the single-dose and multidose pharmacokinetics and safety of a modified, compounded theophylline (MCT) product...

Author(s)
Reinhart, J. M.; Perkowski, C.; Lester, C.; Campos, V.; Kadotani, S.; Li Zhong; McKiernan, B. C.; Fries, R.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2021, 44, 6, pp 902-909
Abstract

Dogs are a potential source of zoonotic Salmonella transmission. We had previously estimated the prevalence of Salmonella shedding among shelter dogs throughout Texas using a repeated cross-sectional study design. Our current objectives were to fully characterize the Salmonella isolates and to...

Author(s)
Cummings, K. J.; Mitchell, P. K.; Rodriguez-Rivera, L. D.; Goodman, L. B.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2020, 6, 4, pp 975-979
Abstract

Periodontal disease (PD) is one of the most widespread inflammatory diseases in dogs. This disease is initiated by a polymicrobial biofilm in the teeth surface (dental plaque), leading to a local inflammatory response, with gingivitis and/or several degrees of periodontitis. For instance, the...

Author(s)
Cunha, E.; Valente, S.; Nascimento, M.; Pereira, M.; Tavares, L.; Dias, R.; Oliveira, M.
Publisher
PeerJ, San Francisco, USA
Citation
PeerJ, 2021, 9, 11626,
Abstract

OBJECTIVE: To determine the pharmacokinetics of florfenicol, terbinafine, and betamethasone acetate after topical application to canine auricular skin and the influence of synthetic canine cerumen on pharmacokinetics. SAMPLE: Auricular skin from 6 euthanized shelter dogs (3 females and 3 neutered...

Author(s)
Ehling, S.; Baynes, R. E.; Bäumer, W.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2018, 79, 3, pp 333-341
Abstract

Afoxolaner, an insecticide and acaricide compound of the isoxazoline class, is available for dogs as an oral ectoparasiticide medicine (NexGard®) and as an oral endectoparasiticide medicine in combination with milbemycin oxime (MO), a macrocyclic lactone (NexGard® Spectra). The safety of these two ...

Author(s)
Drag, M.; Tielemans, E.; Mitchell, E.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2022, 45, 4, pp 373-379
Abstract

Osteosarcoma remains the most common primary bone tumour in dogs with half of affected dogs unable to survive 1 year beyond diagnosis. New therapeutic options are needed to improve outcomes for this disease. Recent investigations into potential therapeutic targets have focused on cell surface...

Author(s)
Alegre, F.; Ormonde, A. R.; Godinez, D. R.; Illendula, A.; Bushweller, J. H.; Wittenburg, L. A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 1, pp 52-63
Abstract

Background: Scratching behaviours associated with intradermal (i.d.) injection of pruritogens such as histamine and compound 48/80 into the skin of mice and humans is the commonly used model to advance itch research and drug development. The predictive validity of this model is poorly documented in ...

Author(s)
Banovic, F.; Denley, T.; Blubaugh, A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Dermatology, 2019, 30, 4, pp 325-e91
Abstract

From 50 to 60% of companion animals in the United States are overweight or obese and this obesity rate is rising. As obesity is associated with a number of health problems, an agent that can help weight loss in pets and assist in clinically managing obesity through veterinary prescription foods and ...

Author(s)
Kim ChoWon; Go RyeoEun; Lee HongKyu; Kang ByeongTeck; Cho WooJae; Choi KyungChul
Publisher
Canadian Veterinary Medical Association, Ottawa, Canada
Citation
Canadian Journal of Veterinary Research, 2021, 85, 3, pp 177-185

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