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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

Theophylline is a commonly used bronchodilator drug for treatment of chronic canine bronchitis, but no formulations validated in dogs are currently available. An oral, modified and compounded theophylline product (MCT), which could fulfil this need, is available through a USP-compliant, veterinary ...

Author(s)
Cavett, C. L.; Li Zhong; McKiernan, B. C.; Reinhart, J. M.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2019, 42, 6, pp 593-601
Abstract

Compounding of drugs for use in veterinary oncology is becoming increasingly common. We obtained 15 mg cyclophosphamide capsules from five different compounding pharmacies and performed potency analyses at two time points, as well as stability at 60 days. Potency results for four out of five and...

Author(s)
Robat, C.; Budde, J.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2017, 15, 3, pp 706-709
Abstract

Osteosarcoma remains the most common primary bone tumour in dogs with half of affected dogs unable to survive 1 year beyond diagnosis. New therapeutic options are needed to improve outcomes for this disease. Recent investigations into potential therapeutic targets have focused on cell surface...

Author(s)
Alegre, F.; Ormonde, A. R.; Godinez, D. R.; Illendula, A.; Bushweller, J. H.; Wittenburg, L. A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 1, pp 52-63
Abstract

Background: Scratching behaviours associated with intradermal (i.d.) injection of pruritogens such as histamine and compound 48/80 into the skin of mice and humans is the commonly used model to advance itch research and drug development. The predictive validity of this model is poorly documented in ...

Author(s)
Banovic, F.; Denley, T.; Blubaugh, A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Dermatology, 2019, 30, 4, pp 325-e91
Abstract

Background: NSAIDs are accepted as the most predictably efficacious medical treatment of the clinical signs of osteoarthritis (OA). The marine-based fatty-acid compound PCSO-524 has been proposed as an adjunctive treatment for canine OA, however benefits of this agent is still controversial. The...

Author(s)
Vijarnsorn, M.; Kwananocha, I.; Kashemsant, N.; Jarudecha, T.; Lekcharoensuk, C.; Beale, B.; Peirone, B.; Lascelles, B. D. X.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 349, pp (17 October 2019)
Abstract

Epilepsy is a common, complex and often challenging neurological disorder to treat in the dog, with 20-30% of dogs resistant to conventional medical therapies, and associated with cognitive and behavioral comorbidities and early death. Behavioral interventions are an emerging area of focus in the...

Author(s)
Packer, R. M. A.; Hobbs, S. L.; Blackwell, E. J.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2019, 6, January, pp 3
Abstract

Trilostane is a synthetic steroid analog used to treat canine hyperadrenocorticism. For small dogs, the dose found in commercially available dosage forms of trilostane is sometimes too high. Compounding trilostane in a liquid diluent provides an option for more precise dosing and adjustments, and...

Author(s)
Crosby, J.; Brown, S.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2017, 228, pp 15-17
Abstract

Background: Canine leishmaniasis is a zoonotic disease caused by Leishmania infantum, being the dogs one of the major reservoirs of human visceral leishmaniasis. DNA topology is a consolidated target for drug discovery. In this regard, topoisomerase IB - one of the enzymes controlling DNA topology...

Author(s)
Reguera, R. M.; Álvarez-Velilla, R.; Domínguez-Asenjo, B.; Gutiérrez-Corbo, C.; Balaña-Fouce, R.; Cushman, M.; Pérez-Pertejo, Y.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 405, pp (09 November 2019)
Abstract

Background: Bacterial densities likely fluctuate during infection and may exceed the bacterial density used in susceptibility testing. As such, investigation of bacterial killing by antibiotics over a range of varying bacterial densities may provide important differences between compounds and could ...

Author(s)
Blondeau, J. M.; Fitch, S. D.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Dermatology, 2020, 31, 3, pp 187-e39
Abstract

Background: Chemotherapeutic options for the treatment of canine lymphoma have not changed in several decades necessitating the identification of new therapeutics to improve patient outcome. KPT-335 (verdinexor) is a novel orally bioavailable selective inhibitor of nuclear export (SINE) that...

Author(s)
Sadowski, A. R.; Gardner, H. L.; Borgatti, A.; Wilson, H.; Vail, D. M.; Lachowicz, J.; Manley, C.; Turner, A.; Klein, M. K.; Waite, A.; Sahora, A.; London, C. A.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2018, 14, 250, pp (24 August 2018)

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