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Abstract

Canine lymphoma is one of the most common malignant tumours occurring in dogs and has a high incidence worldwide. Despite advances in cancer prevention, the treatment of neoplastic diseases still requires improvement. Some cancer cells may resist the effect of chemotherapeutic agents by...

Author(s)
Chen, W.; Liu, I.; Tomiyasu, H.; Lee, J.; Cheng, C.; Liao, A. T.; Liu, B.; Liu, C.; Lin, C.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 254, pp 105398
Abstract

Opioid receptor activation was shown to enhance the efficacy of anti-neoplastic drugs in several human cancer cell lines. In these cell lines, doxorubicin increased the number of opioid receptors and methadone concurrently enhanced cellular doxorubicin uptake. Triggered through lay press and media, ...

Author(s)
Cueni, C.; Nytko, K. J.; Thumser-Henner, P.; Weyland, M. S.; Bley, C. R.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2020, 6, 3, pp 283-289
Abstract

The aim of this pilot study was to evaluate the cardioprotective effects of carvedilol in dogs receiving doxorubicin chemotherapy and provide suggestions to future studies based on results and limitations of our study. Thirteen dogs were randomized into two experimental groups: 6 dogs in carvedilol ...

Author(s)
Pino, E. H. M.; Weber, M. N.; Oliveira, L. O. de; Vieira, L. C.; Santos, K. H. S. dos; Liu, I. P.; Gomes, H. M.; Trindade-Gerardi, A. B.; Moreira, J. C. F.; Gerardi, D. G.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2021, 135, pp 532-541
Abstract

Canine hemangiosarcoma (HSA) is an aggressive malignant endothelial tumor in dogs and characterized by poor prognosis because of its high invasiveness, high metastatic potential, and poor responsiveness to anti-cancer drugs. Although doxorubicin-based chemotherapy is regularly conducted after...

Author(s)
Morita, A.; Aoshima, K.; Gulay, K. C. M.; Onishi, S.; Shibata, Y.; Yasui, H.; Kobayashi, A.; Kimura, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2019, 127, pp 1-10
Abstract

Background: Chemotherapy-induced alopecia (CIA) is common in humans, but there are limited reports describing the clinical features of CIA in dogs. Objectives: To describe the epidemiological and clinical characteristics of doxorubicin-associated alopecia (DAA) in canine patients at a teaching...

Author(s)
Falk, E. F.; Lam, A. T. H.; Barber, L. G.; Ferrer, L.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Dermatology, 2017, 28, 2, pp e48
Abstract

Background: Doxorubicin (DOX) is one of the most effective chemotherapeutics for canine high-grade lymphoma. In addition to dose-dependent chronic cardiotoxicity, DOX can trigger acute cardiac arrhythmias during drug infusion. Diphenhydramine premedication is commonly used, as histamine release is...

Author(s)
Willcox, J. L.; Belanger, C.; Burton, J. H.; Yu, L.; Ueda, Y.; Visser, L. C.; Skorupski, K.; Stern, J. A.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2020, 6, July,
Abstract

Hemangiosarcoma (HSA) is a highly malignant tumour with aggressive biological behaviour. HSAs are more common in dogs than other domestic animals. The median survival time of dogs with HSA remains short, even with chemotherapy and surgery. Therefore, there is a critical need to improve the adjuvant ...

Author(s)
Carlson, A.; Alderete, K. S.; Grant, M. K. O.; Seelig, D. M.; Sharkey, L. C.; Zordoky, B. N. M.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 2, pp 253-261
Abstract

Background: Osteosarcoma (OSA) is a common bone tumor of mesenchymal origin in dogs. Chemotherapy delays metastasis, yet most dogs die of this disease within 1 year of diagnosis. The high metabolic demand of cancer cells promotes proton pump upregulation, leading to acidification of the tumor...

Author(s)
Poon, A. C.; Inkol, J. M.; Luu, A. K.; Mutsaers, A. J.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 2, pp 800-811
Abstract

Chemotherapeutic drugs are given parenterally to treat various canine tumors. A limitation of parenteral administration is low drug penetration into the tumor, which reduces tumoricidal activity. Various drug carriers have been used to enhance tumor delivery, including albumin, liposomes and...

Author(s)
Stokol, T.; Wan, C.; Blakely, R.; Bellat, V.; Law, B.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2020, 128, pp 86-89
Abstract

OBJECTIVE: To assess the in vitro effects of doxorubicin and tetrathiomolybdate (TM) on cells from a canine hemangiosarcoma cell line. SAMPLE: Cultured cells from the canine hemangiosarcoma-derived cell line DEN-HSA. PROCEDURES: Cells were treated with TM (0 to 1.5 µM), doxorubicin (0 to 5 µM), or...

Author(s)
Sloan, C. Q.; Rodriguez, C. O., Jr.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2018, 79, 2, pp 219-225

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