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Abstract

Dogs with ligated common bile ducts were used to determine effects of cholestasis on pharmacokinetics of digoxin and digitoxin. Forty-three dogs were assigned to: group 1-sham-operated controls (n=13); group 2-dogs with ligated common bile duct (n=17); group 3-dogs given phenobarbital for 2 weeks...

Author(s)
Miyazawa, Y.; Sato, T.; Kobayashi, K.; Akahori, F.; Suzuki, T.; Miyashita, H.
Citation
American Journal of Veterinary Research, 1990, 51, 4, pp 605-610
Abstract

Fifteen dogs were divided into 3 groups: a control (C) group of sham-operated dogs, a common bile duct ligation (L) group, and a phenobarbital pretreatment (P) group given phenobarbital for 2 weeks followed by ligation of the common bile duct. Digitoxin was given as a single intravenous...

Author(s)
Miyazawa, Y.
Citation
Journal of the Japan Veterinary Medical Association, 1987, 40, 2, pp 83-88
Abstract

Plasma kinetics of 3H-labelled digoxin and digitoxin in normal dogs and dogs with heart diease followed first-order exponential decay after a single i/v dose. The early rapid decrease in plasma glycoside concentration seemed to represent mixing in the intravascular compartment followed by tissue...

Author(s)
Breznock, E. M.
Citation
American Journal of Veterinary Research, 1973, 34, No.8, pp 993-999
Abstract

In adult cows injected with 1.1, 11 or 20 mg digitoxin (3, 17-37 and 31-55 mu g/kg bodyweight) maximum plasma levels of 1.5, 7.6 and 8.7-25 ng/ml were reached 15, 30 and 30 minutes after injection. Signs of cardiac effect were just detectable after treatment with 11 mg. With 20 mg digitoxin heart...

Author(s)
Weissmuller, A.
Publisher
Tierarztliche Fakultat, Ludwig-Maximilians Universitat, Munchen,
Citation
Untersuchungen uber den Abbau von Digitoxin nach intravenoser Applikation beim Rind unter Berucksichtigung der Konzentration im Plasma und der Herzfrequenz., 1982, pp 80pp.
Abstract

Digoxin and digitoxin were given orally in powder and as an alcoholic solution and i/v to normal dogs and to dogs with congestive heart failure. In normal dogs, left ventricular contractility was monitored by intracardiac manometry, and in dogs with spontaneously occurring right heart failure,...

Author(s)
Hamlin, R. L.; Dutta, S.; Smith, C. R.
Citation
American Journal of Veterinary Research, 1971, 32, No. 9, pp 1391-1398
Abstract

Five dogs treated with 2 or 3 mg of digitoxin a day for nine days were also given 800 mg quinidine on the 7th day, for two days. No dogs showed signs of digitalis poisoning. Plasma levels, elimination half-life and total body clearance time of digitoxin were little affected by quinidine. Plasma...

Author(s)
Peters, D. N.; Hamlin, R. L.; Powers, J. D.
Citation
Journal of Veterinary Pharmacology and Therapeutics, 1981, 4, 4, pp 271-275
Abstract

Author(s)
Harly, G.
Publisher
École Nationale Vétérinaire d'Alfort,
Citation
Digitoxine et digoxine. Emploi en médecine canine. Mesure des concentrations plasmatiques chez le chien., 1983, pp 90pp.
Abstract

Serum protein binding was measured in healthy dogs (25) and in dogs with inflammatory diseases (21) for lidocaine, oxprenolol and propranolol, which bind mainly to α1-acid glycoprotein (α1-AGP), and for diazepam, digitoxin and phenytoin, which bind mainly to albumin. For the drugs mostly bound to α...

Author(s)
Belpaire, F. M.; Rick, A. de; Dello, C.; Fraeyman, N.; Bogaert, M. G.
Citation
Journal of Veterinary Pharmacology and Therapeutics, 1987, 10, 1, pp 43-48
Abstract

Author(s)
Ozaki, H.; Nishimura, R.
Citation
Journal of Veterinary Medicine, Japan, 1998, 51, 8, pp 681-689
Abstract

Author(s)
Zedtwitz-Liebenstein, A.
Publisher
Veterinarmedizinische Universitat, Vienna, Austria
Citation
Measurement of digitoxin concentration in the blood of dogs after single intravenous, oral and repetitive administration. of thesis, 1982, pp 2pp.

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