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AbstractFull Text

The objective of the present study is to evaluate and compare the effect of changes in MIC, efficacy rates of difloxacin and orbifloxacin in the treatment of bacterial infections caused by E. coli or S. intermedius in dogs. The PK/PD modeling was performed to determine the efficacy of oral...

Author(s)
Paiva, G. S.; Silva, G. M. da; Canassa, M. E.; Wosiacki, S. R.; Ferrante, M.
Publisher
Pubvet, Maringá, Brazil
Citation
PUBVET, 2018, 12, 11, pp a204
Abstract

The antibacterial activity, selection of Escherichia coli (E. coli) mutants and mechanisms of fluoroquinolone resistance were investigated by integrating the minimum inhibitory concentration (MIC), mutant prevention concentration (MPC) and in vitro dynamic model approaches. Difloxacin and...

Author(s)
Gebru, E.; Damte, D.; Choi MyungJin; Lee SeungJin; Kim YoungHoan; Park SeungChun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Microbiology, 2012, 154, 3/4, pp 384-394
AbstractFull Text

The aim of the present paper was to evaluate the anti-Leishmania activity of 3 different protocols of treatment (miltefosine plus allopurinol, difloxacin cloridrate plus metronidazole and meglumine antimoniate plus allopurinol) in 42 dogs naturally infected by L. infantum, during a 24-months...

Author(s)
Ariti, G.; Nardoni, S.; Papini, R.; Mugnaini, L.; Giannetti, G.; Bizzeti, M.; Fanetti, N.; Mancianti, F.
Publisher
Polskie Towarzystwo Nauk Weterynaryjnych, Lublin, Poland
Citation
Medycyna Weterynaryjna, 2013, 69, 2, pp 109-111
Abstract

Background - The problem of antibacterial drug resistance is increasing worldwide, in part due to the therapeutic concentrations currently used based on the minimal inhibitory concentration (MIC) as a measure of potency are often the very concentrations required to selectively enrich the resistant...

Author(s)
Awji, E. G.; Tassew, D. D.; Lee JoongSu; Lee SeungJin; Choi MyungJin; Reza, M. A.; Rhee ManHee; Kim TaeHwan; Park SeungChun
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Dermatology, 2012, 23, 4, pp 376-e69
Abstract

In this study, 908 bacterial pathogens from defined infections of dogs and cats were tested for their susceptibility to the novel fluoroquinolone pradofloxacin, which was approved in 2011 for use in cats and dogs. Most of the bacteria tested (Staphylococcus aureus, Staphylococcus pseudintermedius, ...

Author(s)
Schink, A. K.; Kadlec, K.; Hauschild, T.; Michael, G. B.; Dörner, J. C.; Ludwig, C.; Werckenthin, C.; Hehnen, H. R.; Stephan, B.; Schwarz, S.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Microbiology, 2013, 162, 1, pp 119-126
Abstract

Background: Fluoroquinolones are often used interchangeably in dogs and cats. Hypothesis: Predicted therapeutic efficacy differs among fluoroquinolones. Animals: Bacterial pathogens isolated from dogs and cats. Methods: Using microtube-dilution procedures, percent resistance and 2...

Author(s)
Boothe, D. M.; Boeckh, A.; Simpson, R. B.; Dubose, K.
Publisher
American College of Veterinary Internal Medicine, Lakewood, USA
Citation
Journal of Veterinary Internal Medicine, 2006, 20, 6, pp 1297-1306
Abstract

The in vitro activity of difloxacin against canine bacterial isolates from clinical cases was studied in the United States and The Netherlands. Minimal inhibitory concentrations (MIC), the postantibiotic effect, the effect of pH on antimicrobial activity, and the bacterial killing rate tests were...

Author(s)
Hoven, R. van den; Wagenaar, J. A.; Walker, R. D.
Citation
Journal of Veterinary Diagnostic Investigation, 2000, 12, 3, pp 218-223
Abstract

The pharmacokinetics after oral application of the fluoroquinolones (FQs), enrofloxacin (Baytril tablets), difloxacin (Dicural Palatabs), marbofloxacin (Marbocyl) and orbifloxacin (Orbax) were compared in independent crossover studies in Beagle dogs (n=34). Commercially available tablet...

Author(s)
Heinen, E.
Publisher
Blackwell Science, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2002, 25, 1, pp 1-5
Abstract

Infections with antimicrobial-resistant bacteria are a great challenge in both human and veterinary medicine. The purpose of this study was to determine antimicrobial susceptibility of 106 strains of Pseudomonas aeruginosa isolated from dogs with otitis and pyoderma from 2003 to 2006 in the United...

Author(s)
Rubin, J.; Walker, R. D.; Blickenstaff, K.; Bodeis-Jones, S.; Zhao, S.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Microbiology, 2008, 131, 1/2, pp 164-172
Abstract

Objectives: To compare the intrinsic activity of pradofloxacin, a new fluoroquinolone developed for use in veterinary medicine, with other fluoroquinolones, against anaerobic bacteria isolated from dogs and cats. Methods: One hundred and forty-one anaerobes were isolated from dogs and cats and...

Author(s)
Silley, P.; Stephan, B.; Greife, H. A.; Pridmore, A.
Publisher
Oxford University Press, Oxford, UK
Citation
Journal of Antimicrobial Chemotherapy, 2007, 60, 5, pp 999-1003

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