The objective of the present study is to evaluate and compare the effect of changes in MIC, efficacy rates of difloxacin and orbifloxacin in the treatment of bacterial infections caused by E. coli or S. intermedius in dogs. The PK/PD modeling was performed to determine the efficacy of oral...

The antibacterial activity, selection of Escherichia coli (E. coli) mutants and mechanisms of fluoroquinolone resistance were investigated by integrating the minimum inhibitory concentration (MIC), mutant prevention concentration (MPC) and in vitro dynamic model approaches. Difloxacin and...

The aim of the present paper was to evaluate the anti-Leishmania activity of 3 different protocols of treatment (miltefosine plus allopurinol, difloxacin cloridrate plus metronidazole and meglumine antimoniate plus allopurinol) in 42 dogs naturally infected by L. infantum, during a 24-months...

Background - The problem of antibacterial drug resistance is increasing worldwide, in part due to the therapeutic concentrations currently used based on the minimal inhibitory concentration (MIC) as a measure of potency are often the very concentrations required to selectively enrich the resistant...

In this study, 908 bacterial pathogens from defined infections of dogs and cats were tested for their susceptibility to the novel fluoroquinolone pradofloxacin, which was approved in 2011 for use in cats and dogs. Most of the bacteria tested (Staphylococcus aureus, Staphylococcus pseudintermedius, ...

Background: Fluoroquinolones are often used interchangeably in dogs and cats. Hypothesis: Predicted therapeutic efficacy differs among fluoroquinolones. Animals: Bacterial pathogens isolated from dogs and cats. Methods: Using microtube-dilution procedures, percent resistance and 2...

The in vitro activity of difloxacin against canine bacterial isolates from clinical cases was studied in the United States and The Netherlands. Minimal inhibitory concentrations (MIC), the postantibiotic effect, the effect of pH on antimicrobial activity, and the bacterial killing rate tests were...

The pharmacokinetics after oral application of the fluoroquinolones (FQs), enrofloxacin (Baytril tablets), difloxacin (Dicural Palatabs), marbofloxacin (Marbocyl) and orbifloxacin (Orbax) were compared in independent crossover studies in Beagle dogs (n=34). Commercially available tablet...

Infections with antimicrobial-resistant bacteria are a great challenge in both human and veterinary medicine. The purpose of this study was to determine antimicrobial susceptibility of 106 strains of Pseudomonas aeruginosa isolated from dogs with otitis and pyoderma from 2003 to 2006 in the United...

Objectives: To compare the intrinsic activity of pradofloxacin, a new fluoroquinolone developed for use in veterinary medicine, with other fluoroquinolones, against anaerobic bacteria isolated from dogs and cats. Methods: One hundred and forty-one anaerobes were isolated from dogs and cats and...