Background: Oral mycophenolate mofetil (MMF) currently is considered a low-risk steroid-sparing therapeutic option for the management of canine pemphigus foliaceus (PF). Objectives: This retrospective study evaluates the therapeutic outcomes of dogs with PF treated with the combination of oral MMF...

Objectives: To determine whether administration of intravenous hydrocortisone is a safe and effective alternative treatment in comparison to the traditional treatment with prednisolone/dexamethasone in dogs presenting with Addisonian crisis; and to assess if there is any advantage of the former...

OBJECTIVE: To quantify plasma concentrations of prednisolone and dexamethasone (peripheral and jugular) and cortisol following topical ophthalmic application of 1% prednisolone acetate and 0.1% dexamethasone to healthy adult dogs. ANIMALS: 12 purpose-bred Beagles. PROCEDURES: Dogs received 1 drop...

To explore the clinical effect of basic fibroblast growth factor (bFGF) on corneal healing in dogs after penetrating keratoplasty (PKP), thirty-six healthy dogs were selected as recipient dogs and were assigned to one of the four groups (n=9); the surgical control group (A), the dexamethasone group ...

Cyclosporine and glucocorticoids are powerful immunosuppressive agents used to treat many inflammatory diseases in dogs. Cyclosporine inhibits calcineurin-dependent pathways of T cell activation and resultant T cell cytokine production, and glucocorticoids directly inhibit genes coding for...

The dog is an underrepresented large animal translational model for orthopedic cell-based tissue engineering. While chondrogenic differentiation of canine multipotent stromal cells (cMSCs) has been reported using the classic micromass technique, cMSCs respond inconsistently to this method. The...

From 50 to 60% of companion animals in the United States are overweight or obese and this obesity rate is rising. As obesity is associated with a number of health problems, an agent that can help weight loss in pets and assist in clinically managing obesity through veterinary prescription foods and ...

Dexamethasone is the glucocorticoid of choice in many human inflammatory and immune-mediated conditions, given its reported effectiveness and limited side effect profile. In veterinary medicine, the glucocorticoid of choice is prednisone, however the safety of longer-term use of dexamethasone has...

Background: The low-dose dexamethasone suppression test (LDDT) is considered an accurate screening and valuable differentiation test in dogs with suspected hyperadrenocorticism (HAC). A recent study showed that the different response patterns not only provide complementary information about...

Cushing's syndrome is the group of clinical signs caused by hyperadrenocorticism that affects medium to old age dogs, with a predilection in certain breeds and females. In 85% of naturally occurring cases, they are pituitary-dependent and only 15% have their origin in the adrenal glands. An...