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Abstract

Objective: Cytarabine, a cell-cycle phase-specific antimetabolite, has been reported to improve outcomes in dogs with bone marrow (BM) or central nervous system (CNS) lymphoma involvement receiving combination chemotherapy. The objective of this study was to evaluate the incidence and severity of...

Author(s)
Guillen, A.; Finotello, R.; Harper, A.; Killick, D.; Amores-Fuster, I.; Blackwood, L.
Publisher
Wiley, Melbourne, Australia
Citation
Australian Veterinary Journal, 2020, 98, 3, pp 69-78
Abstract

A retrospective study was performed to evaluate response rate, time to progression, and toxicity of a bleomycin and cytosine arabinoside (Bleo/Cytarabine) combination protocol for dogs with relapsed lymphoma (LSA). Dogs diagnosed with LSA and previously treated with chemotherapy were included in...

Author(s)
Batschinski, K.; Dervisis, N.; Kitchell, B.; Newman, R.; Erfourth, T.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2018, 54, 3, pp 150-155
Abstract

Background: Prolonged cytotoxic concentrations of cytarabine (CA) are required for maximum cytotoxicity. DepoCyt is a human liposomal cytarabine (LC) product that lasts longer in plasma and CSF compared with free CA (FC). The use of LC has not been evaluated in dogs. Objectives: To perform a LC...

Author(s)
Fuster, I. B. V.; Taylor, A. R.; Smith, A. N.; Duran, S. H.; Ravis, W. R.; Jasper, S. L.; Arnold, R. D.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 4, pp 1563-1569
Abstract

The objective of this study was to evaluate the plasma and serum concentrations of cytarabine (CA) administered via constant rate infusion (CRI) in dogs with meningoencephalomyelitis of unknown etiology (MUE). Nineteen client-owned dogs received a CRI of CA at a dose of 25 mg/m2/h for 8 h as...

Author(s)
Early, P. J.; Crook, K. I.; Williams, L. M.; Davis, E. G.; Muñana, K. R.; Papich, M. G.; Messenger, K. M.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 4, pp 411-414
Abstract

The DMAC protocol (dexamethasone, melphalan, actinomycin-D, cytarabine) has been evaluated in American studies for the treatment of relapsed canine lymphoma, comparing similarly to other rescue protocols. The aim of this study was to evaluate efficacy and toxicity of DMAC, in a larger UK cohort of...

Author(s)
Smallwood, K.; Tanis, J. B.; Grant, I. A.; Blackwood, L.; Killick, D. R.; Amores-Fuster, I.; Elliott, J.; Mas, A.; Harper, A.; Marrington, M.; Finotello, R.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2019, 17, 2, pp 165-173
AbstractFull Text

A 7-year-old, female neutered cross-breed dog was referred to our institution with a history of progressive hind limb weakness, which then progressed to paraplegia. An MRI of the spine revealed severe meningeal infiltrate consistent with lymphoma involvement, located at the level of L2-L7 with...

Author(s)
Treggiari, E.; Arrol, L. P.
Publisher
Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya
Citation
Open Veterinary Journal, 2018, 8, 2, pp 154-159
Abstract

The ability of chemotherapeutic agents to affect the growth of common bacterial pathogens and the relationship between the effects of chemotherapeutics and antimicrobials is largely unknown. The purpose of this study was to describe the susceptibility of canine bacterial isolates to...

Author(s)
Campbell, O.; Gagnon, J.; Rubin, J. E.
Publisher
Wiley, Oxford, UK
Citation
Letters in Applied Microbiology, 2019, 69, 5, pp 353-357
Abstract

The objective of this study was to describe the pharmacokinetics (PK) of cytarabine (CA) after subcutaneous (SC) administration to dogs with meningoencephalomyelitis of unknown etiology (MUE). Twelve dogs received a single SC dose of CA at 50 mg/m2 as part of treatment of MUE. A sparse sampling...

Author(s)
Pastina, B.; Early, P. J.; Bergman, R. L.; Nettifee, J.; Maller, A.; Bray, K. Y.; Waldron, R. J.; Castel, A. M.; Munana, K. R.; Papich, M. G.; Messenger, K. M.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2018, 41, 5, pp 638-643
Abstract

Objective: To describe a case of suspected drug-induced infiltrative lung disease (ILD) and acute respiratory failure associated with the administration of cytarabine and prednisone in a dog requiring mechanical ventilation. Case Summary: A 4.5-year-old, female spayed Yorkshire Terrier presented to ...

Author(s)
Hart, S. K.; Waddell, L.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Emergency and Critical Care, 2016, 26, 6, pp 844-850
Abstract

This crossover study compared the pharmacokinetics of cytarabine in six healthy dogs following intravenous constant rate infusion (CRI) and subcutaneous (SC) administrations, as these are two routes of administration commonly employed in the treatment of meningoencephalitis of unknown etiology....

Author(s)
Crook, K. I.; Early, P. J.; Messenger, K. M.; Muñana, K. R.; Gallagher, R.; Papich, M. G.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2013, 36, 4, pp 408-411

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