Cyclic hematopoiesis is a stem cell disease in which the number of neutrophils and other blood cells oscillates in weekly phases. Autosomal dominant mutations of ELA2, encoding the protease neutrophil elastase, found in lysosome-like granules, cause cyclic hematopoiesis and most cases of the...

A six-month-old male basset hound was referred for intermittent malaise and pyrexia that repeated every 10-11 days. Sequential blood counts and bone marrow aspirates demonstrated severe neutropenia and increased myeloid precursor cells in the bone marrow from day 2 of each cycle. By day 5, the bone ...

Canine cyclic neutropenia is an autosomal recessive disease in which the number of neutrophils, the primary blood phagocyte, oscillates between almost zero and normal values with two week frequency. We previously found that the causative mutation is an insertion of an extra adenine residue within a ...

Transplantation of normal bone marrow cells to a gray collie dog with cyclic neutropenia resulted in normal granulocytopoiesis. The finding suggests that cyclic neutropenia occurs because the hematopoietic stem cells are defective. Because of the similarity of human and canine cyclic neutropenia,...

Case series summary: At different time points spanning 6 months, three adopted feral flea-infested cats, residing in the household of a veterinary technician, became acutely anorexic, lethargic and febrile. Enrichment blood culture/PCR using Bartonella alpha Proteobacteria growth medium (BAPGM)...

Bone marrow cells were collected from normal dogs, normal dogs made neutropenic with cyclophosphamide, and 11 dogs affected with cyclic haematopoiesis (CH) on 3 consecutive days of separate 12- to 14-day cycles. The mononuclear marrow cells from both groups of control dogs and from the CH dogs on...

Two normal collie dogs were given 1200 R total body irradiation followed by successful marrow grafts from their grey collie littermates with cyclic haematopoiesis. During observation periods of 97 and 41 days after grafting, both previously normal recipients showed regular cyclic fluctuations of...

Recombinant canine G-CSF was administered to clinically normal dogs, cyclic-haematopoietic dogs, and dogs undergoing autologous bone marrow transplantation. The clinically normal dogs responded with a dose-dependent increase in WBC count characterized by neutrophilia and monocytosis. The...

Canine cyclic haematopoiesis is an inherited disorder characterized by a grey coat colour and recurrent fluctuations of peripheral blood neutrophils, monocytes, reiculocytes and platelets. The ability (cytopoietic potential) of marrow from dogs with cyclic haematopoiesis to proliferate within...

A laboratory maintained colony of Collies and Collie-Beagle crosses heterozygous for cyclic haematopoiesis CH, also known as cyclic neutropenia, was established. Matings between dogs heterozygous for CH resulted in 110 pups, 28 of which were homozygous for CH. Each of the 28 homozygous CH pups (15...