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Abstract

Canine osteosarcoma is characterized by aggressiveness, easy metastasis to the lungs, and high mortality after standard therapy. Luteolin is a flavonoid found in vegetables and fruits and has diverse functions. Elucidation of the biological mechanisms of luteolin on canine osteosarcoma will enhance ...

Author(s)
Ryu SooMin; Park SunWoo; Lim WhaSun; Song GwonHwa
Publisher
Wiley, Hoboken, USA
Citation
Journal of Cellular Physiology, 2019, 234, 6, pp 9504-9514
AbstractFull Text

Electrochemotherapy (ECT) couples the administration of anticancer drugs with the delivery of electric pulses that increase the drug uptake through the cell membranes, thus resulting in an improved efficacy. This study has evaluated the tolerability and efficacy of the combination of systemic...

Author(s)
Spugnini, E. P.; Vincenzi, B.; Amadio, B.; Baldi, A.
Publisher
Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya
Citation
Open Veterinary Journal, 2019, 9, 1, pp 88-93
Abstract

Myelosupression resulting from chemotherapy has been widely described in veterinary medicine; however, there is limited information relating to alterations in neutrophil function after chemotherapy in dogs with cancer. The aim of this study was to determine the non-proliferative effects of...

Author(s)
Mendez, N.; Alarcón, P.; Millán, C.; Burgos, R. A.; Morera, F. J.; Ojeda, J.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2020, 221,
Abstract

Background: Canine and human osteosarcomas (OS) are notably similar and have a high rate of metastasis. There is a poor understanding of the tumor development process, predisposing causes, and varying levels of aggression among different cell lines. By characterizing newly developed canine...

Author(s)
Wilson-Robles, H.; Franks, K.; Pool, R.; Miller, T.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 357, pp (22 October 2019)
Abstract

Background: Transitional cell carcinoma is the most common bladder cancer of dogs. Cisplatin combined with piroxicam provides superior response rates, but unacceptable rates of nephrotoxicity. Tavocept is a chemoprotectant that has mitigated cisplatin toxicity and decreased the required...

Author(s)
Henry, C. J.; Flesner, B. K.; Bechtel, S. A.; Bryan, J. N.; Tate, D. J.; Selting, K. A.; Lattimer, J. C.; Bryan, M. E.; Grubb, L.; Hausheer, F.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 1, pp 370-376
Abstract

Osteosarcoma (OSA) is the most common primary bone cancer in children, adolescents and dogs. Current combination surgical and chemotherapeutic treatments have increased survival. However, in recurrent or metastatic disease settings, the prognosis significantly decreases, representing an urgent need ...

Author(s)
Inkol, J. M.; Poon, A. C.; Mutsaers, A. J.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 4, pp 559-569
Abstract

Osteosarcoma (OSA) is the most common bone tumor in dogs. Protein phosphatase 2A (PP2A), an evolutionary conserved serine/threonine protein phosphatase, is a crucial tumor suppressor. SET is a PP2A inhibitory protein that directly interacts with PP2A and suppresses its phosphatase activity. SET has ...

Author(s)
Tsuji, S.; Ohama, T.; Nakagawa, T.; Sato, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 10, pp 1424-1430
Abstract

The anticancer activity of novel platinum derivative, a complex of platinum with tris(2-carboxyethyl)phosphine (Pt-TCEP), has been evaluated in canine (D-17) and human osteosarcoma (U2-OS) cell lines. Viability of cells after incubation for 24 or 72 hours with increasing concentrations (0.625,...

Author(s)
Henklewska, M.; Pawlak, A.; Kutkowska, J.; Pruchnik, H.; Rapak, A.; Obminska-Mrukowicz, B.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2019, 17, 4, pp 497-506
Abstract

Background: Dogs with appendicular osteosarcoma (OSA) receiving standard amputation and adjuvant chemotherapy demonstrate variable outcome with treatment; however, additional biomarkers would be helpful for predicting their outcome. In the present study, we assessed the potential of circulating...

Author(s)
Heishima, K.; Meuten, T.; Yoshida, K.; Mori, T.; Thamm, D. H.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 39, pp (25 January 2019)
Abstract

Canine squamous cell carcinoma (cSCC) is the second most common cutaneous neoplasm in dogs. Treatment options are limited. Electrochemotherapy (ECT) has been proposed as an alternative treatment for many types of tumours. To describe the use of ECT as treatment for generalised cSCC. An adult dog...

Author(s)
Boncea, A. M.; Cristea, A.; Bourdeau, P.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2019, 7, 1, pp e000787

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