Background: Immunophenotyping has replaced cytochemical staining as the preferred technique for classifying acute leukemia. However, some acute myeloid leukemias (AML) lack lineage-associated markers. In our experience, alkaline phosphatase (ALP) is expressed in immature canine monocytes. We...

Traditionally, classification of leukaemia in dogs has relied on morphological examination and cytochemical staining patterns, but aberrant cellular morphology and stain uptake often curtails accurate categorization, and historical data based on this classification may be unreliable....

Background: Leukemias are malign neoplasias of the hematopoietic precursor cells from the bone marrow. These neoplastic cells may or may not reach the blood circulation. Leukemias are classified as lymphoid or myeloid depending on the leukocyte cell lineage affected. In addition, leukemias are...

Utilizing a panel of 30 monoclonal antibodies, canine leukaemias were assessed by flow cytometry alone or by flow cytometry in combination with immunocytochemical staining of smears. Canine chronic lymphocytic leukaemia (CLL) occurred in older dogs (mean age 9.75 years; range 1.5-15 years; 73...

Zeta-chain-associated protein (ZAP-70) and spleen tyrosine kinase (Syk) are structurally and functionally homologous tyrosine kinases playing a role in the T- and B-cell signal transduction. Their activation can lead to lymphokine production, cytolitic activity, antibody secretion, cell...

There are two main clinical forms of leukemia described in dogs and cats, acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). ALL occurs in young adult animals in middle age, characterized by the presence of lymphoblasts in the blood and bone marrow. To differentiate...

This article aims at the presentation of chronic leukemias in dog and cat. Progressive, malignant diseases of bone marrow are classified into acute leukemias, myeloproliferative neoplasms and myelodysplastic syndromes. Myeloproliferative neoplasms together with chronic lymphocytic lymphomas are...

Lymphoid leukemias are malignant neoplasms of lymphocytes originating primarily in the bone marrow. Lymphoid leukemias include both acute lymphoblastic leukemia and chronic lymphocytic leukemia. Both forms are considered uncommon and may mimic more common diseases, such as lymphoma or chronic...

Pathological analysis of malignant histiocytoma and clinical lymphoma in dogs and cats were classified by the WHO classification methods 2013. It can be used for histological identification through HE staining, immunohistochemistry and gene rearrangement. The pathological examination of the 1 dog...

The aim of this study was to conduct a haematological evaluation of dogs and cats in Lima, Peru. A total of 460 blood samples (410 dogs and 50 cats) were collected between December 2017 and May 2018. The smears were stained with Wright and the reticulocytes were stained with Brilliant cresyl blue....