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Abstract

Background: Immune system involvement is suggested as an underlying cause for Doberman hepatitis (DH) based on female predisposition, lymphocyte infiltration, abnormal hepatocyte expression of major histocompatibility complex class II antigens, and homozygosity for dog leukocyte antigen DRB1*00601. ...

Author(s)
Dyggve, H.; Meri, S.; Spillmann, T.; Jarva, H.; Speeti, M.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2017, 31, 6, pp 1717-1723
Abstract

Doberman hepatitis (DH) is a chronic and progressive inflammatory liver disease that mainly affects female dogs. The high incidence of chronic hepatitis in Dobermans is suggestive of a genetic predisposition. DH is characterized by mononuclear cell infiltration and copper accumulation in the liver...

Author(s)
Dyggve, H.; Kennedy, L. J.; Meri, S.; Spillmann, T.; Lohi, H.; Speeti, M.
Publisher
Blackwell Publishing, Copenhagen, Denmark
Citation
Tissue Antigens, 2011, 77, 1, pp 30-35
Abstract

Canine chronic hepatitis is the most common disease of the liver parenchyma. Chronic hepatitis can be found in all breeds of dogs, but in some breeds such as the Bedlington terrier, Labrador retriever, Doberman pincher and English springer spaniel the disease is more common than in others. The ...

Author(s)
Blomqvist, A. C.; Speeti, M.; Wiberg, M.
Publisher
Suomen Eläinlääkäriliitto, Helsinki, Finland
Citation
Suomen Eläinlääkärilehti, 2017, 123, 5, pp 263-270
Abstract

To determine the incidence of hepatic diseases in dogs and cats in Japan, a retrospective study was performed using data of 463 canine and 71 feline liver biopsies at the Veterinary Medical Center of the University of Tokyo. The most common canine hepatic disease was microvascular dysplasia (MVD)...

Author(s)
Hirose, N.; Uchida, K.; Kanemoto, H.; Ohno, K.; Chambers, J. K.; Nakayama, H.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2014, 76, 7, pp 1015-1020
Abstract

Chronic hepatitis is an important clinical syndrome in dogs. In addition to an idiopathic group, several other disorders are now recognized that present as chronic hepatitis but do not appear to have an immune mediated basis. The most important of these disorders include: chronic hepatitis in...

Author(s)
Glińska-Suchocka, K.
Publisher
Elamed Wydawnictwo, Katowice, Poland
Citation
Weterynaria w Praktyce, 2009, 6, 1/2, pp 16-18
AbstractFull Text

Author(s)
Twedt, D. C.
Publisher
North American Veterinary Community (NAVC), Gainesville, USA
Citation
Proceedings of the NAVC Conference, 18-22 January 2014, Orlando, Florida, USA. Volume 28, Small Animal & Exotics, 2014, pp unpaginated
Abstract

Chronic hepatitis in Doberman pinschers is predominantly seen in female dogs, usually between 4 and 7 years of age and was first recognized in the early eighties. The histopathological characteristics of Doberman hepatitis are those of micronodular cirrhosis with histological features of fibrosis,...

Author(s)
Mandigers, P. J. J.; Ingh, T. S. G. A. M. van den; Spee, B.; Penning, L. C.; Bode, P.; Rothuizen, J.
Publisher
Euroscience, Bilthoven, Netherlands
Citation
Veterinary Quarterly, 2004, 26, 3, pp 99-106
Abstract

Major histocompatibility complex (MHC) class II antigen expression in hepatocytes and its correlation with mononuclear cell infiltration into the liver were studied using immunohistochemical techniques in 38 Dobermans with Doberman hepatitis (DH). Liver biopsy samples were obtained from 18 dogs at...

Author(s)
Speeti, M.; Ståhls, A.; Meri, S.; Westermarck, E.
Publisher
Elsevier Science B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2003, 96, 1/2, pp 1-12
AbstractFull Text

Author(s)
Verburgh-Hoffmann, G.
Publisher
World Small Animal Veterinary Association, Geneva, Switzerland
Citation
35th World Small Animal Veterinary Association Congress, Geneva, Switzerland, 2-5 June 2010, 2010, pp unpaginated
Abstract

To investigate whether Dobermanns have impaired copper excretion an intravenous radioactive copper isotope (64Cu) was used as a tracer. Five patients and eight normal dogs (5 normal Dobermanns and 3 Beagles) were studied. The five female Dobermann patients had a subclinical hepatitis and an...

Author(s)
Mandigers, P. J. J.; Bode, P.; Wees, A. M. T. C. van; Brom, W. E. van den; Ingh, T. S. G. A. M. van den; Rothuizen, J.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Research in Veterinary Science, 2007, 83, 2, pp 204-209

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