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Abstract

OBJECTIVE: To develop and analytically validate a liquid chromatography-tandem mass spectrometry method for measurement of endogenous trans-4-hydroxy-L-proline concentrations in canine serum and to assess serum trans-4-hydroxy-L-proline concentrations in dogs with chronic hepatitis. SAMPLE: Serum...

Author(s)
Lawrence, Y. A.; Rodrigues-Hoffmann, A.; Steiner, J. M.; Suchodolski, J. S.; Shankar, S.; Klemashevich, C. L.; Lidbury, J. A.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2019, 80, 5, pp 434-440
Abstract

Chronic hepatitis is the most common hepatic disease in dogs. Copper accumulation is an important cause of chronic hepatitis in dogs; however, the etiology in most dogs cannot be determined. Clinical signs of chronic hepatitis are often non-specific; therefore, this disease is frequently diagnosed...

Author(s)
Lawrence, Y. A.; Dangott, L. J.; Rodrigues-Hoffmann, A.; Steiner, J. M.; Suchodolski, J. S.; Lidbury, J. A.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2018, 13, 11, pp e0208394
Abstract

Although chronic hepatitis is a common diagnosis in the dog, it is usually idiopathic. One proven cause is the COMMD1 mutation in Bedlington terriers resulting in chronic hepatitis due to copper toxicity. Chronic hepatitis occurs in middle-aged to older dogs of any breed, although certain breeds...

Author(s)
Eulenberg, V. M.; Mischel, M. M. M.; Steiner, J. M.
Publisher
Verlag M. & H, Schaper Gmbh, Hannover, Germany
Citation
Kleintierpraxis, 2018, 63, 1, pp 21-38
AbstractFull Text

Aim: This study was performed to evaluate the diagnostic value of hepatocyte-derived microRNA (miRNA)-122 in acute and chronic hepatitis of dogs. Materials and Methods: A total of 26 dogs presented at Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Cairo University, 16 dogs out of 26...

Author(s)
Eman, S. R.; Kubesy, A. A.; Baraka, T. A.; Torad, F. A.; Shaymaa, I. S.; Mohammed, F. F.
Publisher
Veterinary World, Rajkot, India
Citation
Veterinary World, 2018, 11, 5, pp 667-673
Abstract

Background: Chronic hepatopathies present a diagnostic challenge, with different diseases being associated with similar clinical and laboratory findings. Characterization of dogs with chronic hepatopathies can be difficult and require costly diagnostic procedures such as acquisition of a liver...

Author(s)
Lawrence, Y. A.; Bishop, M. A.; Honneffer, J. B.; Cook, A. K.; Rodrigues-Hoffmann, A.; Steiner, J. M.; Suchodolski, J. S.; Lidbury, J. A.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 3, pp 1344-1352
Abstract

Background: Only one study reports prednisone to prolong survival in dogs with chronic hepatitis irrespective of the causative agent. The aim of this retrospective study was to investigate the effects of prednisolone treatment on survival, clinicopathological variables, and histological grade and...

Author(s)
Favier, R. P.; Poldervaart, J. H.; Ingh, T. S. G. A. M. van den; Penning, L. C.; Rothuizen, J.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Veterinary Quarterly, 2013, 33, 3, pp 113-120
AbstractFull Text

Primary hepatitis (PH) is one of the most frequently diagnosed hepatic diseases in dogs. Its popular forms are acute hepatitis (AH) and chronic active hepatitis (CAH) which can progress to hepatic fibrosis and cirrhosis. This investigation aimed to evaluate the use of hepatocyte released Canine...

Author(s)
El-Sebaey, A. M.; Abramov, P. N.; Borunova, S. M.
Publisher
Peoples' Friendship University of Russia (RUDN University), Moscow, Russia
Citation
RUDN Journal of Agronomy and Animal Industries, 2020, 15, 3, pp 294-307
Abstract

Accurate staging of hepatic fibrosis (HF) is important for treatment and prognosis of canine chronic hepatitis. HF scores are used in human medicine to indirectly stage and monitor HF, decreasing the need for liver biopsy. We developed a canine HF score to screen for moderate or greater HF. We...

Author(s)
Menard, M.; Lecoindre, A.; Cadoré, J. L.; Chevallier, M.; Pagnon, A.; Hernandez, J.; Leal, R. O.; Hugonnard, M.; Miette, V.; Destro, M.; Rannou, B.; Benchekroun, G.; Lecoindre, P.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2019, 31, 5, pp 665-673
Abstract

Hepatocellular carcinomas (HCC) represent an important part of hepatic diseases in dogs, correspond to more than 50% of primary neoplasms of the liver in this species. HCC affects, mainly, males over 10 years old, presenting poor prognosis in patients not suitable for surgery. Latest years, studies ...

Author(s)
Salas-Gómez, D.
Publisher
Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, Brazil
Citation
Avaliação mutacional do gene TP53 no carcinoma hepatocelular em cães: uma abordagem comparativa, 2019, pp 78 pp.
Abstract

Serum canine α1-proteinase inhibitor (cα1-PI) concentrations were evaluated in dogs with pancreatitis (n=24), exocrine pancreatic insufficiency (EPI; n=29), chronic hepatitis (CH; n=11) or proteinuric chronic kidney disease (CKD-P; n=61) to determine whether systemic proteinase/proteinase-inhibitor ...

Author(s)
Heilmann, R. M.; Grützner, N.; Hokamp, J. A.; Lidbury, J. A.; Xenoulis, P. G.; Suchodolski, J. S.; Nabity, M. B.; Cianciolo, R.; Steiner, J. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2018, 236, pp 68-71

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