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Abstract

Most modern pet species have awide breed variability. The genetic aspect plays a significant role in the development of individual pathologies. A retrogen encoding fibroblast growth factor 4 (FGF4), when inserted into the chromosome 18of dogs (CFA18), leads to chondrodysplasia, phenotypically...

Author(s)
Kuznetsova, T.; Semenov, B.; Mikhailova, A.; Markova, A.; Filippova, E.; Bychkova, E.
Publisher
Sankt-Peterburgskaya gosudarstvennaya akademiya veterinarnoy meditsiny, St Petersburg, Russia
Citation
Mezhdunarodnyy vestnik veterinarii, 2020, 1, pp 128-134
Abstract

Chondrodysplasia is a type of genetic skeletal disorder associated with abnormalities in the development of cartilage tissues. Affected dogs suffer from disproportionate short-limbed dwarfism and/or hyperplasia of the skull bones. Visible symptoms occur only during growth period. Early studies...

Author(s)
Florczuk, P.; Gruszczyńnska, J.
Publisher
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie, Szczecin, Poland
Citation
Acta Scientiarum Polonorum - Zootechnica, 2016, 15, 4, pp 5-14
Abstract

In morphological terms, "form" is used to describe an object's shape and size. In dogs, facial form is stunningly diverse. Facial retrusion, the proximodistal shortening of the snout and widening of the hard palate is common to brachycephalic dogs and is a welfare concern, as the incidence of...

Author(s)
Marchant, T. W.; Johnson, E. J.; McTeir, L.; Johnson, C. I.; Schoenebeck, J. J.
Publisher
Cell Press, Cambridge, USA
Citation
Current Biology, 2017, 27, 11, pp 1573-1584.e6
Abstract

Background: Lethal chondrodysplasia (bulldog syndrome) is a well-known congenital syndrome in cattle and occurs sporadically in many breeds. In 2015, it was noticed that about 12% of the offspring of the phenotypically normal Danish Holstein sire VH Cadiz Captivo showed chondrodysplasia resembling...

Author(s)
Agerholm, J. S.; Menzi, F.; McEvoy, F. J.; Jagannathan, V.; Drögemüller, C.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2016, 12, 100, pp (13 June 2016)
Abstract

Canine chondrodysplasia is a heritable defect of endochondral ossification characterized by disproportionately short limbs. It is directly linked to significant health concerns, such as intervertebral disc disease. Some human skeletal dysplasias exhibit similar disproportionate dwarfisms and are...

Author(s)
Young, A. E.; Bannasch, D. L.
Publisher
Taylor & Francis, Washington, USA
Citation
Animal Biotechnology, 2008, 19, 1, pp 1-5
Abstract

Background: The bulldog calf syndrome is a lethal form of the inherited congenital chondrodysplasias. Among the progeny of the polled Holstein bull Energy P cases of lethal chondrodysplasia were observed. Pedigrees of the cases and the frequency of 3/8 cases among the offspring of Energy P at our...

Author(s)
Reinartz, S.; Mohwinkel, H.; Sürie, C.; Hellige, M.; Feige, K.; Eikelberg, D.; Beineke, A.; Metzger, J.; Distl, O.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2017, 18, 762, pp (10 October 2017)
Abstract

Type 10 collagen alpha 1 (COL10A1) is a short-chain collagen of cartilage synthesized by chondrocytes during the growth of long bones. COL10A1 mutations, which frequently result in COL10A1 haploinsufficiency, have been identified in patients with Schmid metaphyseal chondrodysplasia (SMCD), a...

Author(s)
Young, A. E.; Ryun, J. R.; Bannasch, D. L.
Publisher
Springer-Verlag, New York, USA
Citation
Mammalian Genome, 2006, 17, 7, pp 761-768
Abstract

Chondrodysplasia (CD) is a disabling, hereditary disease in Labradors with short limbs, warranting genetic screening in families at risk. Segregation analysis of eight litters with 13 affected dogs showed that autosomal recessive inheritance was consistent with the observed incidence of CD in the...

Author(s)
Smit, J. J.; Temwitchitr, J.; Brocks, B. A. W.; Nikkels, P. G. J.; Hazewinkel, H. A. W.; Leegwater, P. A. J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2011, 187, 2, pp 269-271
Abstract

Retrotransposition of processed mRNAs is a common source of novel sequence acquired during the evolution of genomes. Although the vast majority of retroposed gene copies, or retrogenes, rapidly accumulate debilitating mutations that disrupt the reading frame, a small percentage become new genes...

Author(s)
Parker, H. G.; Vonholdt, B. M.; Quignon, P.; Margulies, E. H.; Shao, S.; Mosher, D. S.; Spady, T. C.; Elkahloun, A.; Cargill, M.; Jones, P. G.; Maslen, C. L.; Acland, G. M.; Sutter, N. B.; Kuroki, K.; Bustamante, C. D.; Wayne, R. K.; Ostrander, E. A.
Publisher
American Association for the Advancement of Science, Washington, USA
Citation
Science (Washington), 2009, 325, 5943, pp 995-998
AbstractFull Text

Case description - A three-month-old male German Shepherd dog, with signs of instability to stand, ataxia and radiographic symptoms of chondrodysplasia is presented. The symptoms were developed since birth. Clinical Findings - On physical examination, the affected pup did not show any swelling,...

Author(s)
Mosallanejad, B.; Ghadiri, A.; Avizeh, R.
Publisher
Iranian Veterinary Surgery Association, Kermen, Iran
Citation
Iranian Journal of Veterinary Surgery, 2007, 2, 4, pp 89-93

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