In the canine specie, there are few studies that demonstrate the occurrence of adverse endocrine alterations to neoplasms or antineoplastic therapies. The objectives of this project include the assessment of cortisol levels and metabolic parameters in dogs with mast cell tumors before or after...

Mast cell tumor is a common canine cutaneous neoplasm with variable biological behavior. Many studies in the literature evaluate predictive and prognostic factors for this neoplasm. The tumoral progression is an important phenomenon for many neoplasms, and in the canine prostatic neoplasm and...

Cutaneous mast cell tumours are one of the most common canine cancers. Approximately 25% of the tumours metastasise. Activating c-kit mutations are present in about 20% of tumours, but metastases occur in the absence of mutations. Tumour metastasis is associated with significantly diminished...

Cancer is one of the most important lethal diseases for dogs. Nevertheless, most aspects of the cause and development of canine cancer are still unknown. Aim of the projects included in this thesis was therefore to obtain deeper insights into the molecular carcinogenesis of canine mammary tumors, ...

Canine mast cell tumor is a malignant neoplasm, and a gold standard treatment remains to be determined despite the proposed chemotherapies or other therapies in dogs. This study aimed to determine therapeutic, adverse effects and toxicity, tumor-free, and overall survival times of 10 dogs with...

Cutaneous and subcutaneous mast cell tumours are common neoplasms in the dog. While the majority can be treated with adequate local therapy alone, a subset demonstrates a biologically aggressive behaviour associated with local recurrence or metastasis. This article reviews the diagnosis and tumour...

The objective of the study was to determine whether neoadjuvant prednisone therapy affects histological features of cutaneous and subcutaneous mast cell tumors. Twenty-eight dogs with a treatment naïve > 1-cm diameter mast cell tumor (MCT) were randomly assigned (Random number generator;...

In canine cutaneous mast cell tumours (cMCTs), histologic grade and clinical stage are the most important prognostic factors, with high-grade tumours and metastatic lymph nodes (LNs) significantly influencing the evolution of disease. However, it is uncertain whether histologic grade and clinical...

Mast cell tumour (MCT) is a common cancer in dogs, this type of tumour has a variable biological behaviour which is why the chosen therapeutic management will be different depending on the case. The aim of this case report is to describe the evolution of a canine mast cell tumour and its response...

A 14-year-old, female, spayed warren hound presented with an acute history of collapse, pale mucous membranes and abdominal distension. Abdominal ultrasound and abdominocentesis revealed a haemoabdomen secondary to a ruptured splenic mass. The dog underwent an emergency splenectomy and splenic...