Turnover of carnitine in the body is primarily the result of renal excretion, and high-fat (HF) diets have been shown to increase urine carnitine excretion in healthy people. Recently, increased renal excretion of carnitine was observed in dogs (n=18) diagnosed with cystinuria and carnitine ...

In this overview of success stories in veterinary clinical nutrition topics in cats and dogs reviewed include the dietary management of chronic kidney disease, dissolution of urinary tract uroliths by dietary modification, the recognition that taurine and L-carnitine deficiencies can cause dilated...

Some newer more promising therapies for dogs with dilated cardiomyopathy (DCM) do not involve drugs but rather nutritional supplements. Two of the more common nutritional supplements administered to dogs with DCM are taurine and carnitine. Deficiencies of these nutrients have been shown to cause...

This paper discussed the different causes of dilated cardiomyopathy (DCM) in dogs with focused on giving dogs with grain-free diets, how grain free diets lead to dilated cardiomyopathy and how to manage DCM in cases where the dog had DCM due to grain free diets and dogs with no sign of DCM but...

Five client-owned dogs with cystinuria were diagnosed with carnitine and taurine deficiency while participating in a clinical trial that used dietary management of their urolithiasis. Stored 24 h urine samples collected from the cystinuric dogs before enrollment in the clinical diet trial were...

This study was conducted to determine whether the late onset form of inherited ceroid lipofuscinosis (CL) in Tibetan Terriers is accompanied by low plasma carnitine concentrations prior to the appearance of clinical signs. 129 healthy Tibetan Terriers, 12 Tibetan Terriers with CL, and 95 healthy...

The article describes the etiology of disease and general symptoms at first. Furthermore is discussed in detail occurrence and specific symptoms of cardiomyopathy in the breed Great Dane. This article presents two clinical cases. In conclusion is discussed in brief illness relationship with ...

Exercise intolerance syndromes are well known to be associated with inborn errors of metabolism affecting glycolysis (phosphorylase and phosphofructokinase deficiency) and fatty acid oxidation (palmitoyl carnitine transferase deficiency). We have identified a canine model for profound exercise...

A study was conducted to assess morphologic and metabolic abnormalities in 7 Beagle dogs with early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP). Plasma carnitine concentrations were measured before and after development of ELVD induced by RRVP. At the same...

This study was conducted to evaluate plasma taurine concentrations (PTC), whole blood taurine concentrations (WBTC), and echocardiographic findings in 17 healthy Beagle dogs fed 1 of 3 protein-restricted diets that varied in fat and L-carnitine content. Baseline PTC and WBTC were determined, and...