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Abstract

Smaller dogs are known to have an increased risk of chemotherapy-induced myelosuppression for doxorubicin, mitoxantrone and melphalan. This retrospective study aimed to determine if dogs <15 kg and <10 kg experienced greater degrees of myelosuppression following treatment with carboplatin chemotherapy compared with dogs ≥15 kg. One hundred and one dogs treated with carboplatin for a...

Author(s)
Coffee, C.; Roush, J. K.; Higginbotham, M. L.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 4, pp 804-810
Abstract

Carboplatin is used to treat certain cancers in dogs and cats and is routinely administered via intravenous drip (IVD). Subcutaneous (SC) administration has also been described. However, the toxicity, serum concentrations, and area under blood concentration-time curves (AUCs) of SC carboplatin are...

Author(s)
Iwano, M.; Sadahiro, K.; Maruo, T.; Kawarai, S.; Kayanuma, H.; Orito, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2021, 83, 5, pp 775-779
Abstract

Despite numerous published studies describing adjuvant chemotherapy for canine appendicular osteosarcoma, there is no consensus as to the optimal chemotherapy protocol. The purpose of this study was to determine whether either of two protocols would be associated with longer disease-free interval...

Author(s)
Skorupski, K. A.; Uhl, J. M.; Szivek, A.; Frazier, S. D. A.; Rebhun, R. B.; Rodriguez, C. O., Jr.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2016, 14, 1, pp 81-87
AbstractFull Text

Background: Melanoma is the most frequent cancer in the canine oral cavity. It shows an aggressive behavior, characterized by rapid and invasive growth and high metastatic potential. Metastasis is seen in more than 80% of dogs at time of death. Adjuvant therapy should be recommended because of...

Author(s)
Lavalle, G. E.; Caires, C. E. T.; Teixeira, S. V.; Castro Cunha, R. M. de; Carneiro, R. A.
Publisher
Universidade Federal do Rio Grande do Sul, Faculdade de Veterinária, Porto Alegre, Brazil
Citation
Acta Scientiae Veterinariae, 2021, 49, 1808,
Abstract

5-Fluorouracil (5-FU) is used in combination chemotherapy protocols for human head and neck cancer and other epithelial neoplasms. However, a paucity of literature describing use of this drug in veterinary oncology exists, likely due to previous reports of fatal neurotoxicity in both dogs and cats, ...

Author(s)
Menard, K.; Flesner, B. K.; Glahn, A.; Boudreaux, B.; Bryan, J. N.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 4, pp 590-595
Abstract

Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) of prostate and urinary bladder are highly invasive and metastatic tumors of closely neighbored organs. Cell lines are valuable tools to investigate tumor mechanisms and therapeutic approaches in vitro. PAC in dogs is...

Author(s)
Packeiser, E. M.; Hewicker-Trautwein, M.; Thiemeyer, H.; Mohr, A.; Junginger, J.; Schille, J. T.; Escobar, H. M.; Nolte, I.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2020, 15, 3,
Abstract

OBJECTIVE: To evaluate adverse events and outcomes in dogs with appendicular osteosarcoma treated with limb amputation followed by a single SC infusion of carboplatin. ANIMALS: 45 client-owned dogs with appendicular osteosarcoma treated with limb amputation and SC infusion of carboplatin between...

Author(s)
Santamaria, A. C.; Simcock, J. O.; Kuntz, C. A.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2019, 255, 3, pp 345-351
Abstract

Osteosarcoma, a common malignancy in large dog breeds, typically metastasises from long bones to lungs and is usually fatal within 1 to 2 years of diagnosis. Better therapies are needed for canine patients and their human counterparts, a third of whom die within 5 years of diagnosis. We compared...

Author(s)
Patatsos, K.; Shekhar, T. M.; Hawkins, C. J.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 4, pp 544-553
Abstract

Osteosarcoma (OSA) is the most common primary bone cancer in children, adolescents and dogs. Current combination surgical and chemotherapeutic treatments have increased survival. However, in recurrent or metastatic disease settings, the prognosis significantly decreases, representing an urgent need ...

Author(s)
Inkol, J. M.; Poon, A. C.; Mutsaers, A. J.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 4, pp 559-569
Abstract

Osteosarcoma (OSA) is the most common malignant bone cancer in children and dogs. The therapeutic protocols adopted for dogs and humans are very similar, involving surgical options such as amputation. Besides surgical options, radiotherapy and chemotherapy also are adopted. However, hematologic,...

Author(s)
Rici, R. E. G.; Will, S. E. A. L.; Luna, A. C. L.; Melo, L. F.; Santos, A. C.; Rodrigues, R. F.; Leandro, R. M.; Maria, D. A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 4, pp 478-488

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