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VetMed Resource

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Abstract

Background: Dogs can suffer from inappetence caused by a variety of medical conditions. This may present as anorexia (complete loss of appetite), hyporexia (decreased appetite) or dysrexia (change in food preferences). A drug with a new mechanism of action, capromorelin, has potential to stimulate...

Author(s)
Zollers, B.; Rhodes, L.; Heinen, E.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2017, 13, 10, pp (5 January 2017)
Abstract

The objective of the study was to evaluate the safety of capromorelin, a ghrelin agonist that stimulates appetite and causes increased body weight and the release of growth hormone (GH). Beagle dogs (n=32) received either oral placebo or 0.3, 7, or 40 mg/kg capromorelin once daily for 12...

Author(s)
Zollers, B.; Huebner, M.; Armintrout, G.; Rausch-Derra, L. C.; Rhodes, L.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 3, pp 248-255
Abstract

Background: Reduced appetite is a common clinical sign in dogs. This study evaluated the effectiveness and safety of capromorelin oral solution, (ENTYCE®, Aratana Therapeutics, Leawood, KS) a new drug that is a ghrelin receptor agonist, for stimulation of appetite in dogs with reduced appetite....

Author(s)
Zollers, B.; Wofford, J. A.; Heinen, E.; Huebner, M.; Rhodes, L.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2016, 30, 6, pp 1851-1857
Abstract

Capromorelin is a ghrelin receptor agonist that is FDA approved for appetite stimulation in dogs. The objective of this study was to evaluate the safety of daily oral administration of capromorelin to cats over a range of doses and for an extended period. Two randomized, controlled studies were...

Author(s)
Wofford, J. A.; Zollers, B.; Rhodes, L.; Bell, M.; Heinen, E.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2018, 41, 2, pp 324-333
Abstract

This study's objective was to determine the effects in dogs of oral capromorelin, a ghrelin agonist, at different doses for 7 days on food consumption, body weight and serum concentrations of growth hormone (GH), insulin-like growth factor 1 (IGF-1), and cortisol. Adult Beagles (n=6) were dosed...

Author(s)
Zollers, B.; Rhodes, L.; Smith, R. G.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 2, pp 140-147
Abstract

Ghrelin is a hormone, secreted from cells in the stomach, which is important in the regulation of appetite and food intake in mammals. It exerts its action by binding to a specific G-protein-coupled receptor, the growth hormone secretagogue receptor 1a (GHS-R1a) which is found in areas of the brain ...

Author(s)
Rhodes, L.; Zollers, B.; Wofford, J. A.; Heinen, E.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2018, 4, 1, pp 3-16
Abstract

Poor appetite is a common clinical complaint in patients with chronic kidney disease. Nurses can play an important role by helping to perform regular nutritional assessment to identify patients that require intervention. This article aims to discuss the importance of this clinical problem and the...

Author(s)
Quimby, J. M.
Publisher
MA Healthcare Limited, London, UK
Citation
The Veterinary Nurse, 2018, 9, 7, pp 366-370
Abstract

Author(s)
Johannes, C. M.; Musser, M. L.
Publisher
Eastern States Veterinary Association, Inc (NAVC), Glen Mills, USA
Citation
Today's Veterinary Practice, 2019, 9, 4, pp 70-74
Abstract

Author(s)
Gough, A.
Publisher
Veterinary Business Development Ltd, Peterborough, UK
Citation
Veterinary Times, 2018, 48, 19, pp 10
AbstractFull Text

Author(s)
Robertson, S. A.
Publisher
North American Veterinary Community (NAVC), Orlando, USA
Citation
North American Veterinary Community (NAVC) Veterinary Meeting & Expo (VMX 2020), Orlando, Florida, USA. Small animal & exotics - Book 1 & Book 2. Proceedings, 2020, pp 352-355

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