Osteosarcoma (OSA) is the most common primary bone tumor in both dogs and humans. The dog is an important research model for OSA, yet dogs have much higher prevalence of bone tumors than do humans, a disparity that has yet to be explained. Neoplastic transformation of cells within or adjacent to ...

This issue contains 18 topics on the histological grading systems for neoplasms in veterinary medicine; validating immunohistochemistry assay specificity in investigative studies; radiographic and histologic correlation of bone tumours in dogs and cats; value, limitations and recommendations for...

Few studies have investigated the diagnostic performance of fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) for staging veterinary patients with appendicular osteosarcoma. The purpose of this study was to evaluate the efficacy of ¹⁸F-FDG-PET/CT...

The use of tyrosine kinase inhibitors (TKI) has gained significant importance in veterinary cancer patients over the last decade. Toceranib phosphate has been licensed for the treatment of dogs with mast cell tumours. Its molecular similarity to sunitinib, a TKI used in human medicine, has led many ...

Sertoli cell tumours are one of the most common canine testicular neoplasia. These tumours are significantly more likely to arise in cryptorchid dogs and are often functional, oestrogen-secreting tumours which can lead to fatal myelotoxicity. The goal of this study was to describe the outcome of ...

This retrospective study describes the MRI features of extradural spinal neoplasia in 60 dogs and seven cats to identify potential distinguishing features between tumor classes and individual tumor types within each class. In dogs, mesenchymal tumors were most common (48%), with undifferentiated...

Hypertrophic osteopathy is a paraneoplastic disorder characterized by periosteal bone neoformation that is usually associated with primary neoplasms or pulmonary metastases. The diagnosis is made through history, anamnesis, physical and radiographic examinations. The treatment is based on...

Objective: To determine the influence of neoplasia on the biomechanical properties of canine antebrachia. Study design: Ex vivo biomechanical study. Sample population: Osteosarcoma (OSA)-affected canine antebrachia (n=12) and unaffected canine antebrachia (n=9). Methods: Antebrachia were compressed ...

Cyclooxygenase (COX) isoforms-1 and -2 have been extensively investigated in cancer. Although COX-2 is the isoform most studied and has been described in several malignancies associated with histologic criteria of malignancy and worse prognosis, COX-1 has also been linked to some forms of cancer....

Background: Medical infrared thermal imaging (MITI) is a noninvasive imaging modality used in veterinary medicine as a screening tool for musculoskeletal and neurological disease processes. An infrared camera measures the surface body heat and produces a color map that represents the heat...