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Abstract

Osteosarcoma is the most common paediatric primary bone malignancy. The major cause of death in osteosarcoma is drug-resistant pulmonary metastasis. Previous studies have shown that thioredoxin reductase 2 is a driver of metastasis in osteosarcoma and can be inhibited by auranofin (AF). Moreover,...

Author(s)
Endo-Munoz, L.; Bennett, T. C.; Topkas, E.; Wu, S. Y.; Thamm, D. H.; Brockley, L.; Cooper, M.; Sommerville, S.; Thomson, M.; O'Connell, K.; Lane, A.; Bird, G.; Peaston, A.; Matigian, N.; Straw, R. C.; Saunders, N. A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 2, pp 206-213
AbstractFull Text

Author(s)
Nap, R. C.
Publisher
World Small Animal Veterinary Association, Cape Town, South Africa
Citation
39th World Small Animal Veterinary Association Congress, Cape Town, South Africa, 16-19 September 2014. Proceedings book, 2014, pp 674-678
Abstract

The use of gold salt therapy (chrysotherapy) in the treatment of several diseases of altered immunoregulation has been increasing. In this review, topics discussed are the pharmacological and pharmacokinetic features, the mechanism of action, toxicity and side effects and dosage and administration.

Author(s)
Serra, D. A.; White, S. D.
Citation
Journal of the American Veterinary Medical Association, 1989, 194, 9, pp 1327-1330
Abstract

In two seven-year studies with gold compounds in dogs of both sexes, thrombocytopenia was observed after 45 to 72 months of dosing in three of 14 and two of 14 dogs in high-dose groups that received 2.4 to 3.6 mg/kg of auranofin per day orally or 0.5 to 2.0 mg/kg of gold sodium thiomalate...

Author(s)
Bloom, J. C.; Blackmer, S. A.; Bugelski, P. J.; Sowinski, J. M.; Saunders, L. Z.
Citation
Veterinary Pathology, 1985, 22, 5, pp 492-499
Abstract

Author(s)
Bloom, J. C.; Bugelski, P. J.; Saunders, L. Z.
Citation
Veterinary Clinical Pathology, 1984, 13, 1, pp 29

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