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Abstract

Immunotherapy targeting immune checkpoint molecules, programmed cell death 1 (PD-1) and PD-ligand 1 (PD-L1), using therapeutic antibodies has been widely used for some human malignancies in the last 5 years. A costimulatory receptor, PD-1, is expressed on T cells and suppresses effector functions...

Author(s)
Maekawa, N.; Konnai, S.; Takagi, S.; Kagawa, Y.; Okagawa, T.; Nishimori, A.; Ikebuchi, R.; Izumi, Y.; Deguchi, T.; Nakajima, C.; Kato, Y.; Yamamoto, K.; Uemura, H.; Suzuki, Y.; Murata, S.; Ohashi, K.
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2017, 7, 1, pp 8951
AbstractFull Text

Electrochemotherapy (ECT) couples the administration of anticancer drugs with the delivery of electric pulses that increase the drug uptake through the cell membranes, thus resulting in an improved efficacy. This study has evaluated the tolerability and efficacy of the combination of systemic...

Author(s)
Spugnini, E. P.; Vincenzi, B.; Amadio, B.; Baldi, A.
Publisher
Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya
Citation
Open Veterinary Journal, 2019, 9, 1, pp 88-93
Abstract

The Hedgehog-GLI signaling pathway is activated in human and canine osteosarcoma (OSA) and represents a potential therapeutic target for cancers, including OSA. Arsenic trioxide represses GLI expression. Melarsomine, an arsenic compound-containing drug, has been approved for the treatment of canine ...

Author(s)
Nam ArYung; Kim TaeWon; Li Qiang; Rebhun, R. B.; Youn HwaYoung; Seo KyoungWon
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 12, pp 1722-1729
Abstract

Background: Mammary cancer has a high incidence in canines and is an excellent model of spontaneous carcinogenesis. Molecular iodine (I2) exerts antineoplastic effects on different cancer cells activating re-differentiation pathways. In co-administration with anthracyclines, I2 impairs...

Author(s)
Zambrano-Estrada, X.; Landaverde-Quiroz, B.; Dueñas-Bocanegra, A. A.; Paz-Campos, M. A. de; Hernández-Alberto, G.; Solorio-Perusquia, B.; Trejo-Mandujano, M.; Pérez-Guerrero, L.; Delgado-González, E.; Anguiano, B.; Aceves, C.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2018, 14, 87, pp (12 March 2018)
Abstract

The absence of an effective therapy against human solid tumors has fostered the development of promising antineoplastic therapeutic candidates, as the CIGB-552 peptide. This synthetic peptide has shown to be effective in reducing tumor size and increasing the lifespan in tumor-bearing mice....

Author(s)
Vallespi, M. G.; Rodriguez, J. C.; Seoane, L. C.; Alvarez, P.; Santana, H.; Garay, H.; Cabrera, I. A.; Espinosa, J. T.; Reyes, O.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2017, 114, pp 502-510
Abstract

Cancer is one of the most important lethal diseases for dogs. Nevertheless, most aspects of the cause and development of canine cancer are still unknown. Aim of the projects included in this thesis was therefore to obtain deeper insights into the molecular carcinogenesis of canine mammary tumors,...

Author(s)
Klopfleisch, R.
Publisher
Freie Universität Berlin, Berlin, Germany
Citation
Identifikation molekularer Karzinogenesefaktoren und diagnostischer Marker häufiger Tumorarten beim Hund, 2013, pp ii + 53 pp.
Abstract

Receptor tyrosine kinases (RTK) are major promising targets in anticancer therapy in human and veterinary medicine. Using immunohistochemistry method, we evaluated the expression of five types RTK (PDGFR-α, PDGFR-β, VEGFR 2, c-Kit and Abl) in the six canine brain tumor samples (2 meningioma, 2...

Author(s)
Jung HaeWon; Song JoongHyun; Yu DoHyeon; An SuJin; Sur JungHyang; Kim YoungJoo; Han DongHyun; Jung DongIn
Publisher
Korean Society of Veterinary Clinics, Seoul, Korea Republic
Citation
Journal of Veterinary Clinics, 2019, 36, 6, pp 319-324
Abstract

Therapy of canine mammary tumours (CMTs) with classical antitumour drugs is problematic, so better therapeutic options are needed. Palbociclib (PD-0332991) is an innovative and effective anticancer drug for the treatment of breast cancer in women. Palbociclib is an inhibitor of cyclin-dependent...

Author(s)
Schoos, A.; Knab, V. M.; Gabriel, C.; Tripolt, S.; Wagner, D. A.; Bauder, B.; Url, A.; Fux, D. A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2019, 17, 4, pp 507-521
Abstract

Introduction: Methotrexate is an antimetabolite used in the treatment of cancer and non-malignant diseases including rheumatoid arthritis, psoriasis and graft vs. host disease. Combination therapy with methotrexate was successful in the treatment of canine lymphoma, mammary tumor and invasive...

Author(s)
Pawlak, A.; Kutkowska, J.; Obmińska-Mrukowicz, B.; Rapak, A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2017, 114, pp 518-523
Abstract

Osteosarcoma is a mesenchymal malignant bone tumor accompanied by a high rate of lung metastasis and short survival in dogs. Although various therapies have been reported, the etiological mechanism of osteosarcoma remains undetermined and the development of novel therapeutic agents is warranted. In ...

Author(s)
Ryu SooMin; Park SunWoo; Lim WhaSun; Song GwonHwa
Publisher
Wiley, Hoboken, USA
Citation
Journal of Cellular Biochemistry, 2019, 120, 10, pp 17449-17458

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