Alopecia X is a hair cycle arrest disorder in Pomeranians. Histologically, kenogen and telogen hair follicles predominate, whereas anagen follicles are sparse. The induction of anagen relies on the activation of hair follicle stem cells and their subsequent proliferation and differentiation. Stem...

Alopecia in dogs is a frequent finding at veterinary dermatological consultations, may be caused by various skin diseases and even systemic. Alopecia X is a dermatopathy that occurs most often in Nordic breeds, especially in German Spitz dogs, about which there is not much scientific knowledge...

Background: Schipperkes develop bilaterally symmetrical alopecia preceded by lightening of the hair coat not associated with systemic clinical signs. The alopecia is presumptively diagnosed as Alopecia X but has never been investigated. Hypothesis/Objectives: The purpose of this study was to...

Background: Alopecia X in dogs is a noninflammatory alopecia that may be caused by a hormonal dysfunction. It may be similar to androgenic alopecia in men that is caused by the effect of dihydrotestosterone (DHT). The 5α-reductase isoenzymes, 5αR1 and 5αR2, and a recently described 5αR3, are...

Our objective was to characterize the use of 18F-fluorodeoxyglucose (FDG)-PET/CT in the diagnosis of primary splenic hemangiosarcoma in combination with histopathology and immunohistochemistry. A 7-year-old castrated male mixed breed dog weighing 6 kg was presented with the complain of recurring...

Background - Noninflammatory alopecia is a frequent problem in dogs, and the pathogenesis is still unclear. Objective - The objective of this study was a comparative histological description of skin biopsies from dogs with different alopecic disorders and control dogs matched for coat type, season...

Background: Trichoblastoma is a rare skin neoplasm derived from the primitive hair follicle, having epithelial and mesenchymal components. Despite being commonly described as a benign tumor, there are reports in the literature of tumors with characteristics of malignant neoplasia. It affects adult ...

Alopecia in dogs occurs secondary to a variety of underlying inflammatory and noninflammatory conditions. Hair cycle arrest (alopecia X) is a noninflammatory alopecia that is frustrating to diagnose and treat due to lack of understanding of disease pathogenesis. A variety of therapies for hair...

Background: Alopecia X (hair cycle arrest) is a relatively frequent hair growth disorder in Pomeranians and several other breeds, characterized by symmetrical, noninflammatory alopecia without systemic signs. The cause and pathogenesis remain unknown. Previously reported treatments with various...

Background: Alopecia X is a common cause of noninflammatory alopecia in Pomeranian dogs. In the past, treatment with growth hormone injections resulted in hair regrowth in many individuals. Progesterone can induce mammary-derived growth hormone and is used to treat dogs with congenital growth...