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Abstract

Allopurinol is the most commonly used drug for the treatment of hyperuricemia in people, and in view of the risks of fatal hypersensitivity in patients with renal dysfunction, doses based on the glomerular filtration rate are proposed. In veterinary medicine, allopurinol is used in the treatment of ...

Author(s)
Godoy, A. L. P. C.; Jesus, C. de; Gonçalves, R. S.; Azeredo, F. J.; Rocha, A.; Marques, M. P.; Lanchote, V. L.; Larangeira, D. F.; Barrouin-Melo, S. M.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Journal of Pharmaceutical and Biomedical Analysis, 2020, 185,
Abstract

First-line treatment for canine leishmaniosis (CanL) is N-methylglucamine antimoniate (MGA) combined with allopurinol. However, in some dogs allopurinol may induce hyperxanthinuria leading to urolithiasis. Moreover, allopurinol resistance has recently been described in Leishmania infantum isolates...

Author(s)
Segarra, S.; Miró, G.; Montoya, A.; Pardo-Marín, L.; Boqué, N.; Ferrer, L.; Cerón, J.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2017, 239, pp 50-56
Abstract

Leishmania infantum is one of the causative agents of visceral leishmaniasis (VL), a widespread, life-threatening disease. This parasite is responsible for the majority of human VL cases in Brazil, the Middle East, China, Central Asia and the Mediterranean basin. Its main reservoir are domestic ...

Author(s)
Yasur-Landau, D.; Jaffe, C. L.; David, L.; Doron-Faigenboim, A.; Baneth, G.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
International Journal for Parasitology: Drugs and Drug Resistance, 2018, 8, 3, pp 403-410
Abstract

The aim of this 6-month, randomized, blinded, controlled clinical trial was to compare the efficacy and safety of aminosidine-allopurinol combination with that of meglumine antimoniate-allopurinol combination for the treatment of leishmaniosis in dogs without stage III or IV chronic kidney disease. ...

Author(s)
Kasabalis, D.; Chatzis, M. K.; Apostolidis, K.; Petanides, T.; Athanasiou, L. V.; Xenoulis, P. G.; Mataragka, A.; Ikonomopoulos, J.; Leontides, L. S.; Saridomichelakis, M. N.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Experimental Parasitology, 2020, 214,
Abstract

Canine leishmaniosis due to Leishmania infantum is a widespread zoonotic disease. Although aminosidine can be an effective treatment, current therapeutic recommendations do not advocate its use, mainly due to concerns regarding the potential nephrotoxicity and ototoxicity of this drug. The aim of...

Author(s)
Kasabalis, D.; Chatzis, M. K.; Apostolidis, K.; Xenoulis, P. G.; Buono, A.; Petanides, T.; Leontides, L. S.; Polizopoulou, Z. S.; Steiner, J. M.; Suchodolski, J. S.; Saridomichelakis, M. N.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Experimental Parasitology, 2019, 206, pp 107768
Abstract

Background: Visceral leishmaniosis is a potentially life-threatening illness caused by a protozoan parasite of the genus Leishmania. It is found mainly in areas where both the parasite and its vector are endemic and is one of the most challenging infectious diseases in the world to control. HIV...

Author(s)
Manna, L.; Corso, R.; Galiero, G.; Cerrone, A.; Muzj, P.; Gravino, A. E.
Publisher
BioMed Central Ltd, London, UK
Citation
Parasites and Vectors, 2015, 8, 289, pp (28 May 2015)
Abstract

Hepatic fibropoiesis in canine visceral leishmaniasis (CVL) were evaluated by histological (morphometrical collagen deposition) and immunohistochemical assays characterizing alpha-actin (α-SMA), vimentin, calprotectin (L1 antigen), and TGF-β in 46 naturally infected dogs with Leishmania infantum...

Author(s)
Castro, R. S.; Amorim, I. F. G. de; Pereira, R. A.; Silva, S. M.; Pinheiro, L. J.; Pinto, A. J. W.; Azevedo, E. G.; Demicheli, C.; Caliari, M. M. V.; Mosser, D. M.; Michalick, M. S. M.; Frezard, F. J. G.; Tafuri, W. L.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2018, 250, pp 22-29
Abstract

Background: Renal disease is considered the main cause of natural mortality in dogs with canine leishmaniosis. The pathological mechanisms associated with kidney injury in canine leishmaniosis include immune complex glomerulonephritis, tubulointerstitial nephritis and occasionally renal...

Author(s)
Baneth, G.; Segev, G.; Mazaki-Tovi, M.; Chen HiLa; Kuzi, S.
Publisher
BioMed Central Ltd, London, UK
Citation
Parasites and Vectors, 2018, 11, 151, pp (20 March 2018)
Abstract

A 4-year-old crossbreed dog presented with a two-day history of lethargy and abdominal effusion. Physical examination and echocardiography revealed pericardial effusion with cardiac tamponade. Pericardiocentesis was performed. Intracytoplasmic Leishmania amastigotes were found on cytological...

Author(s)
Sebastián-Marcos, P.; Santarelli, G.; Gómez, S.; Fernández-del Palacio, M. J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2019, 23, pp 32-37
Abstract

Background: Visceral leishmaniasis caused by the protozoan Leishmania infantum is a zoonotic, life threatening parasitic disease. Domestic dogs are the main peridomestic reservoir, and allopurinol is the most frequently used drug for the control of infection, alone or in combination with other...

Author(s)
Yasur-Landau, D.; Jaffe, C. L.; David, L.; Baneth, G.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS Neglected Tropical Diseases, 2016, 10, 1, pp e0004341

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