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Abstract

Aglepristone, a competitive progesterone antagonist, is successfully used in various progesterone-dependent conditions. This study investigated uterine histomorphometric analysis, and expressions of the oestrogen α receptor (ERα) and progesterone receptor (PR) in uteri of bitches following the...

Author(s)
Limmanont, C.; Lertwatcharasarakul, P.; Ponglowhapan, S.; Sirinarumitr, K.
Publisher
Wiley, Berlin, Germany
Citation
Reproduction in Domestic Animals, 2021, 56, 7, pp 1015-1023
Abstract

Neoadjuvant treatment of canine mammary carcinomas with the progesterone receptor (PR) antagonist aglepristone has a PR expression-related inhibiting effect on proliferation index (PI). The aim of this study was to evaluate the effect of the treatment in the disease-free period (DFP) and overall...

Author(s)
Guil-Luna, S.; Millán, Y.; Andres, J. de; Rollón, E.; Domingo, V.; García-Macías, J.; Sánchez-Céspedes, R.; Mulas, J. M. de las
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2017, 15, 2, pp 391-399
Abstract

Shear wave elastography (SWE) can be useful to discriminate between malignant and benign mammary tumors. In dogs with elevated progesterone levels compared to the baseline and fast-growing tumors, treatment with the use of aglepristone allows for tumor size reduction, which facilitates surgery....

Author(s)
Pieczewska, B.; Glińska-Suchocka, K.; Niżański, W.; Dzięcioł, M.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2021, 11, 2,
AbstractFull Text

Cystic endometrial hyperplasia-pyometra complex (CEH/P) is a challenge in canine reproduction. Present study aimed to assess fertility after medical treatment. One-hundred-seventy-four bitches affected by CEH/P received aglepristone on days 1, 2, 8, then every 7 days until blood progesterone <1.2 ng/mL; cloprostenol was administered on days 3 to 5. Records were grouped according to bodyweight (BW): small (<10 kg, n=33), medium (10 ≥ BW <25 kg, n=44), large (25 ≥ BW <40 kg, n=52), and giant bitches (BW ≥40 kg, n=45). Age; success rate; ...

Author(s)
Melandri, M.; Veronesi, M. C.; Pisu, M. C.; Majolino, G.; Alonge, S.
Publisher
Korean Society of Veterinary Science, Seoul, Korea Republic
Citation
Journal of Veterinary Science, 2019, 20, 4, pp e39
Abstract

Cystic endometrial hyperplasia - Pyometra complex is a canine endometrial disorder, considered the most common and important among uterine diseases. The treatment of choice is ovariohysterectomy, but medical treatments have become an alternative. However, no studies have been performed in order to...

Author(s)
Rosa Filho, R. R.
Publisher
Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, Brazil
Citation
Avaliação da hemodinâmica uterina em cadelas com piometra submetidas a diferentes protocolos de tratamento medicamentoso, 2019, pp 106 pp.
Abstract

Objective. Evaluate the effectiveness of aglepristone with and without cloprostenol for treating canine pyometra. Materials and methods. Ten female French Bulldogs between 3-8 years of age diagnosed with pyometra were divided into two groups, one receiving a 10 mg/kg dose of aglepristone...

Author(s)
Molina D., V.
Publisher
University of Cordoba, Monteria, Colombia
Citation
Revista MVZ Cordoba, 2015, 20, 2, pp 4636-4645
Abstract

The aim of the study was to evaluate the influence of administration of aglepristone in mid-proestrus on progesterone concentration, LH release, and occurrence of ovulation in the bitch. Experimental bitches (n = 7) were treated on days 4 and 5 of proestrus with aglepristone at the dose of 10 mg/kg ...

Author(s)
Socha, P.; Bladowska, K.; Zduńczyk, S.; Janowski, T.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2021, 11, 7,
Abstract

Background: Progesterone receptors play a key role in the development of canine mammary tumours, and recent research has focussed on their possible value as therapeutic targets using antiprogestins. Cloning and sequencing of the progesterone receptor gene has shown that the receptor has two...

Author(s)
Guil-Luna, S.; Stenvang, J.; Brünner, N.; Andrés, F. J. de; Rollón, E.; Domingo, V.; Sánchez-Céspedes, R.; Millán, Y.; Martín de las Mulas, J.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2014, 10, 296, pp (17 December 2014)
Abstract

In the bitch, ovarian follicular and corpus luteum (CL) development and function are regulated by gonadotropins as well as local factors, the role of which is especially important during the early CL phase of relative gonadotrophic independence. We assumed that insulin-like growth factor 1 (IGF1)...

Author(s)
Balogh, O.; Müller, L.; Boos, A.; Kowalewski, M. P.; Reichler, I. M.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
General and Comparative Endocrinology, 2018, 269, pp 68-74
Abstract

Aglepristone was administered in bitches during the follicular phase to evaluate its effects on progesterone, estradiol-17β and LH serum concentrations. Ten German Shepherds were divided into two groups (treated n = 5; control n = 5). Treated bitches received 10 mg/kg BW of aglepristone...

Author(s)
Troisi, A.; Polisca, A.; Cardinali, L.; Orlandi, R.; Brecchia, G.; Menchetti, L.; Zerani, M.; Maranesi, M.; Mari, W. di; Verstegen, J. P.
Publisher
Wiley, Berlin, Germany
Citation
Reproduction in Domestic Animals, 2020, 55, 12, pp 1794-1802

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