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Abstract

Neoadjuvant treatment of canine mammary carcinomas with the progesterone receptor (PR) antagonist aglepristone has a PR expression-related inhibiting effect on proliferation index (PI). The aim of this study was to evaluate the effect of the treatment in the disease-free period (DFP) and overall...

Author(s)
Guil-Luna, S.; Millán, Y.; Andres, J. de; Rollón, E.; Domingo, V.; García-Macías, J.; Sánchez-Céspedes, R.; Mulas, J. M. de las
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2017, 15, 2, pp 391-399
AbstractFull Text

Cystic endometrial hyperplasia-pyometra complex (CEH/P) is a challenge in canine reproduction. Present study aimed to assess fertility after medical treatment. One-hundred-seventy-four bitches affected by CEH/P received aglepristone on days 1, 2, 8, then every 7 days until blood progesterone <1.2 ng/mL; cloprostenol was administered on days 3 to 5. Records were grouped according to bodyweight (BW): small (<10 kg, n=33), medium (10 ≥ BW <25 kg, n=44), large (25 ≥ BW <40 kg, n=52), and giant bitches (BW ≥40 kg, n=45). Age; success rate; ...

Author(s)
Melandri, M.; Veronesi, M. C.; Pisu, M. C.; Majolino, G.; Alonge, S.
Publisher
Korean Society of Veterinary Science, Seoul, Korea Republic
Citation
Journal of Veterinary Science, 2019, 20, 4, pp e39
Abstract

Background: Progesterone receptors play a key role in the development of canine mammary tumours, and recent research has focussed on their possible value as therapeutic targets using antiprogestins. Cloning and sequencing of the progesterone receptor gene has shown that the receptor has two...

Author(s)
Guil-Luna, S.; Stenvang, J.; Brünner, N.; Andrés, F. J. de; Rollón, E.; Domingo, V.; Sánchez-Céspedes, R.; Millán, Y.; Martín de las Mulas, J.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2014, 10, 296, pp (17 December 2014)
Abstract

Objective. Evaluate the effectiveness of aglepristone with and without cloprostenol for treating canine pyometra. Materials and methods. Ten female French Bulldogs between 3-8 years of age diagnosed with pyometra were divided into two groups, one receiving a 10 mg/kg dose of aglepristone...

Author(s)
Molina D., V.
Publisher
University of Cordoba, Monteria, Colombia
Citation
Revista MVZ Cordoba, 2015, 20, 2, pp 4636-4645
Abstract

In the bitch, ovarian follicular and corpus luteum (CL) development and function are regulated by gonadotropins as well as local factors, the role of which is especially important during the early CL phase of relative gonadotrophic independence. We assumed that insulin-like growth factor 1 (IGF1)...

Author(s)
Balogh, O.; Müller, L.; Boos, A.; Kowalewski, M. P.; Reichler, I. M.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
General and Comparative Endocrinology, 2018, 269, pp 68-74
Abstract

Leptin (LEP) and leptin receptor (LEP-R) expression was shown to change throughout the luteal phase in several species and may be involved in steroid hormone production. In the bitch, leptin but not LEP-R protein was detected in the non-pregnant corpus luteum (CL). Until now, no further information ...

Author(s)
Balogh, O.; Kowalewski, M. P.; Reichler, I. M.
Publisher
Wiley-Blackwell, Berlin, Germany
Citation
Reproduction in Domestic Animals, 2012, 47, s6, pp 40-42
Abstract

The fate of the canine corpus luteum (CL) differs from that of other domestic species: beyond the extended luteal regression observed in both pregnant and non-pregnant cycles, active luteolysis is observed only in pregnant dogs. Luteal regression in the absence of pregnancy lacks a luteolytic...

Author(s)
Papa, P. C.; Kowalewski, M. P.
Publisher
Elsevier, New York, USA
Citation
Theriogenology, 2020, 150, pp 339-346
Abstract

Aglepristone (RU 46534) is a competitive progesterone antagonist that is indicated for the treatment of various progesterone-dependent physiological or pathologic conditions. Aglepristone has proven to be an effective means of terminating pregnancy in most species. When used to induce parturition, ...

Author(s)
Gogny, A.; Fiéni, F.
Publisher
Elsevier, New York, USA
Citation
Theriogenology, 2016, 85, 4, pp 555-566
Abstract

Canine oocyte maturation and fertilization take place within the oviducts under increasing plasma levels of progesterone (P4). In order to investigate the role of P4 in these processes, 51 beagle bitches were treated with the P4 receptor antagonist aglepristone at the end of proestrus and 32...

Author(s)
Reynaud, K.; Saint-Dizier, M.; Tahir, M. Z.; Havard, T.; Harichaux, G.; Labas, V.; Thoumire, S.; Fontbonne, A.; Grimard, B.; Chastant-Maillard, S.
Publisher
Society for the Study of Reproduction, Inc., Madison, USA
Citation
Biology of Reproduction, 2015, 93, 4, pp 87
Abstract

Pyometra is a life-threatening uterine infection that affects 20-25% of reproductively intact bitches. Canine pyometra is characterized by accumulation of leukocytes and exudate within the uterine lumen. Although exact temporal and progressive mechanisms underlying its pathogenesis are not fully...

Author(s)
Kutzler, M.
Publisher
The Society for Theriogenology, Montgomery, USA
Citation
Clinical Theriogenology, 2019, 11, 4, pp 639-648

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