Background: Autoinflammatory diseases in dogs are characterized by complex disease processes with varying clinical signs. In Shar-Pei, signs of inflammation including fever and arthritis are known to be related with a breed-specific predisposition for Shar-Pei Autoinflammatory Disease (SPAID)....

Hereditary periodic fever syndromes are characterized by recurrent episodes of fever and inflammation with no known pathogenic or autoimmune cause. In humans, several genes have been implicated in this group of diseases, but the majority of cases remain unexplained. A similar periodic fever...

A 3-month old male Shar-Pei was presented for lethargy, fever and cutaneous edema. Further investigations revealed superficial pyoderma with Streptococcus canis and an acute neutrophilic vasculitis. Symptomatic and antibiotic treatment in combination with immunosuppressive treatment (initially...

Amyloidosis is an abnormality of protein coagulation when normal whole or parts of soluble proteins are deposit as pathological, insoluble fibers which destroy tissue structure, thereby causing a disease. The deposited structures at a systemic amyloidosis may be present at a parenchyma of internals ...

Renal disease in a Shar-Pei dog is a condition that should make one consider Shar-Pei Fever, but diseases such as nephrotic syndrome, renal amyloidosis, glomerulonephritis, diabetic ketoacidosis, also Lyme disease (in endemic areas) should also be on the list of differential diagnoses, due to their ...

The aim of this article is to present the current state of knowledge concerning the familial diseases of Chinese Shar-pei dogs, with particular emphasis on the pathogenesis and treatment options. Familial Shar-pei fever (FSF) is an autoimmune disease clinically resembling human hereditary periodic ...

Background: Dissecting the role copy number variants (CNVs) play in disease pathogenesis is directly reliant on accurate methods for quantification. The Shar-Pei dog breed is predisposed to a complex autoinflammatory disease with numerous clinical manifestations. One such sign, recurrent fever, was ...

A Chinese shar pei with a 2 yr history of episodic fever, lethargy, and shifting lameness was presumptively diagnosed with familial shar pei fever but had never been treated for the syndrome. After being presented for a superficial pyoderma with possible dermatophyte coinfection, treatment with a...

Shar pei dogs have two unique features: a breed defining "wrinkled" skin phenotype and a genetic disorder called familial shar pei fever (FSF). The wrinkled phenotype is strongly selected for and is the result of excessive hyaluronan (HA) deposited in the skin. HA is a molecule that may behave in a ...