The Pelger-Huët anomaly is a genetic alteration that modifies the morphological characteristics of the immune system's granulocytes, primarily in neutrophils. This alteration has autosomal dominant characteristic and has two possible forms, heterozygous and homozygous. The aim of this study was to...

Pelger-Huët anomaly is an inherited disorder of maturation of myeloid cells, in particular granulocytes and monocytes. Nucleus hyposegmentation, respectively hypolobulation of these cells is the hallmark of Pelger-Huët anomaly. This anomaly is often misinterpreted as inflammatory disease or...

A 6-year-old Australian Shepherd bitch, 28 kg, is presented for dental prophylaxis at the Veterinary Hospital (HV) of the Universidade Estadual de Maringá (UEM), Umuarama, Parana, Brazil. The owner reported that the animal was healthy, vaccinated, and had no recent medications. Physical examination ...

Pelger-Huët anomaly is a rare hereditary disorder characterized by failure of the nucleus of granulocytes, especially neutrophils, to undergo normal maturation to the segmented form. Affected neutrophils have unsegmented or round nuclei, but chromatin condensation and cytoplasmic development...

Pelger Huet anomaly (PHA) is a hereditary disease characterized by non-segmentation of the granulocyte nuclei, especially neutrophils, due to a genetic defect in the lamin B-receptor (LBR) in chromosome 1q41-43. In that disorder, neutrophils present bilobulated, oval or round nuclei, and abundant...

Pelger-Huet (P-H) anomaly is a benign congenital anomaly of leukocytes, characterized by nuclear hyposegmentation of granulocytes. Patients with heterozygous form of P-H anomaly are not immunodeficient and not predisposed to infection. In this study, P-H anomaly has been detected during a routine...

A 13 year old Danish/Swedish Farmdog from Denmark was evaluated in a veterinary clinic in Warsaw, Poland for evaluation of an orthopedic problem. Radiographs revealed spondylosis and degenerative vertebral disease, which responded to treatment with anti-inflammatory medications. A predominance of...

Pelger-Hüet Anomaly (PHA) is an autosomal dominant disorder of granulocytes and monocytes, characterized by abnormal chromatin and nuclear shape in blood granulocytes and monocytes. This article describes two heterozygous canine cases, both Australian shepherds, seen at a veterinary clinic in...

A 6-month-old male mixed-breed dog weighing 12.6 kg weight was presented for evaluation of a subcutaneous nodule on the dorsum. The medical history indicated trimethoprim-sulfamethoxazole treatment 2 months before presentation at the veterinary hospital. The initial complete blood cell count (CBC)...