Background: Little clinical information is available concerning the use of leflunomide in dogs with immune-mediated diseases. Objectives: To report the safety and efficacy of leflunomide for the treatment of naturally occurring immune-mediated diseases in dogs. Animals: Ninety-two dogs treated with ...

Inflammatory colorectal polyps (ICRPs) are frequently observed in miniature dachshunds in Japan and treated by prednisolone and immunosuppressive drugs such as cyclosporine and leflunomide. The purpose of this retrospective study was to compare the treatment efficacy, such as response rate,...

Inflammatory colorectal polyp (ICRP) common in miniature dachshunds, presents with hematochezia, tenesmus and mucoid feces. Although an 80% response rate has been reported when treated with prednisolone and cyclosporine, effective treatment is needed for the remaining 20% of ICRP dogs. Leflunomide...

Canine distemper virus (CDV) is the aetiological agent that causes canine distemper (CD). Currently, no antiviral drugs have been approved for CD treatment. A77 1726 is the active metabolite of the anti-rheumatoid arthritis (RA) drug leflunomide. It inhibits the activity of Janus kinases (JAKs) and ...

A lack of understanding of specific immune defects underlying canine immune-mediated diseases hampers optimal therapy. Failure to tailor treatment to an individual's immune abnormality can result in lack of efficacy, secondary complications, added expense, and drug-potentiated adverse effects. We...

Background: In dogs, the effects of immunosuppressive medications on hemostasis are not well known. Hypothesis/Objectives: The objective was to determine the effects of immunosuppressive medications on primary and secondary hemostasis. Our hypothesis was that cyclosporine and prednisone would...

Objective - To evaluate efficacy and adverse effects of leflunomide for the treatment of naturally occurring immune-mediated polyarthritis (IMPA) in dogs. Design - Retrospective case series. Animals - 14 dogs with cytologically confirmed IMPA. Procedures - Medical records were used to identify dogs ...

A pharmacodynamic assay has been previously developed to monitor ciclosporin treatment in dogs by assessing inhibition of cytokine transcription after whole blood stimulation with 12-myristate 13-1 acetate and ionomycin (PMA/I). In this study, whole blood stimulation with either PMA/I or...

Immunomodulatory and immunosuppressive molecules are used for the therapy of cutaneous lupus, with various success rates depending on the different clinical form considered. Currently, the most effective therapy for vesicular lupus appears to be calcineurin inhibitors, with a good prognosis in 75%...