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Abstract

Severe hemophilia A (HA) is an inherited bleeding disorder characterized by <1% of residual factor VIII (FVIII) clotting activity. The disease affects several mammals including dogs, and, like humans, is associated with high morbidity and mortality. In gene therapy using adeno-associated viral (AAV) vectors, the ...

Author(s)
Callan, M. B.; Haskins, M. E.; Wang Ping; Zhou ShangZhen; High, K. A.; Arruda, V. R.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2016, 11, 3, pp e0151800
Abstract

Continuous expression of activated factor VII (FVIIa) via gene transfer is a potential therapeutic approach for hemophilia patients with or without inhibitory antibodies to human factor VIII (FVIII) or IX (FIX). Here, we investigate whether gene transfer of an engineered canine FVIIa (cFVIIa)...

Author(s)
Margaritis, P.; Roy, E.; Aljamali, M. N.; Downey, H. D.; Giger, U.; Zhou, S. Z.; Merricks, E.; Dillow, A.; Ezban, M.; Nichols, T. C.; High, K. A.
Publisher
American Society of Hematology, Washington, USA
Citation
Blood, 2009, 113, 16, pp 3682-3689
Abstract

Hemophilia B is an x-linked recessive hereditary coagulopathy that has been reported in various species. We describe a male Newfoundland-Parti Standard Poodle hybrid puppy and its family with hemophilia B from clinical manifestations to the molecular genetic defect. The index case presented for...

Author(s)
Kuder, H.; Sandzhieva-Vuzzo, L.; Kehl, A.; Rappaport, J. M.; Müller, E.; Giger, U.
Publisher
MDPI Publishing, Basel, Switzerland
Citation
Genes, 2021, 12, 10,
Abstract

Haemophilias are inherited bleeding disorders caused by low concentrations of specific coagulation factors: deficiencies of factor VIII (haemophilia A) or factor IX (haemophilia B). It is an inherited disorder of haemostasis in dogs and has also been diagnosed in cats, horses, cattle, goats and...

Author(s)
Kuleš, J.; Barić-Rafaj, R.; Mrljak, V.
Publisher
Hrvatski Veterinarski Institut, Centar za Peradarstvo, Zagreb, Croatia
Citation
Veterinarska Stanica, 2010, 41, 4, pp 311-321
Abstract

Management of dogs with haemophilia B requires transfusion of canine blood products supplying active factor IX. Production of inhibitors to factor IX is a complication of transfusion therapy that has been documented as affecting human patients. This appears to be the first report of canine factor ...

Author(s)
Brooks, M. B.; Gu, W.; Ray, K.
Citation
Journal of the American Veterinary Medical Association, 1997, 211, 11, pp 1418-1421
Abstract

Three male German Shepherd pups (littermates) were treated for vaccination-induced haematomas. Coagulation tests in 2 of these pups revealed prolonged activated partial thromboplastin times, whereas specific coagulation factor tests revealed severe deficiency of factor IX activity. Investigation of ...

Author(s)
Feldman, D. G.; Brooks, M. B.; Dodds, W. J.
Citation
Journal of the American Veterinary Medical Association, 1995, 206, 12, pp 1901-1905
Abstract

We undertook the biochemical and molecular characterization of haemophilia in a large pedigree of German wirehaired pointers. Males affected with haemophilia B had approximately 5% normal Factor IX coagulant activity and a proportional reduction of Factor IX protein concentration, indicative of a...

Author(s)
Brooks, M. B.; Gu, W. K.; Barnas, J. L.; Ray, J.; Ray, K.
Publisher
Springer-Verlag New York Inc., New York, USA
Citation
Mammalian Genome, 2003, 14, 11, pp 788-795
Abstract

Cats with spontaneous bleeding due to hemostatic disorders are less often presented compared to dogs. The typical clinical signs of secondary hemostatic disorders (coagulopathies) are bleeding into body cavities, into joints, hematoma formation, and delayed bleeding after trauma. If a coagulopathy...

Author(s)
Kohn, B.
Publisher
Verlag M. & H. Schaper, Alfeld (Leine), Germany
Citation
Kleintierpraxis, 2008, 53, 2, pp 105-112
Abstract

A colony of clotting factor IX (FIX) deficient Lhasa Apso dogs was established and the molecular basis of haemophilia B was determined. The plasma factor IX levels were <1% of normal canine levels in affected dogs. A complex deletion mutation at nucleotides 772-777 was found when hepatocyte cDNA from a...

Author(s)
Mauser, A. E.; Whitlark, J.; Whitney, K. M.; Lothrop, C. D.
Citation
Blood, 1996, 88, 9, pp 3451-3455
Abstract

Objective: To characterize hemostasis and determine if disseminated intravascular coagulation (DIC) is present in cats with cytauxzoonosis. Design: Cross-sectional study. Setting: University teaching hospital. Animals: Five client-owned cats with cytologic and PCR-confirmed cytauxzoonosis....

Author(s)
Conner, B. J.; Hanel, R. M.; Brooks, M. B.; Cohn, L. A.; Birkenheuer, A. J.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Emergency and Critical Care, 2015, 25, 4, pp 538-545

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