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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

Objective: Bedinvetmab is a canine monoclonal antibody targeting nerve growth factor . This study evaluated the efficacy and safety of bedinvetmab for alleviation of pain associated with osteoarthritis in dogs. Study design: Double-blind, randomized, multicentre, placebo-controlled study. Animals:...

Author(s)
Corral, M. J.; Moyaert, H.; Fernandes, T.; Escalada, M.; Kira S. Tena, J.; Walters, R. R.; Stegemann, M. R.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2021, 48, 6, pp 943-955
Abstract

Nerve growth factor (NGF), a critical mediator of nociception, is a novel analgesic therapeutic target. Bedinvetmab, a canine monoclonal antibody (mAb), binds NGF and inhibits its interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. The objective...

Author(s)
Krautmann, M.; Walters, R.; Cole, P.; Tena, J.; Bergeron, L. M.; Messamore, J.; Mwangi, D.; Rai, S.; Dominowski, P.; Saad, K.; Zhu, Y.; Guillot, M.; Chouinard, L.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2021, 276,