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VetMed Resource

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Abstract

P-glycoprotein, encoded by the MDR1 or ABCB1 gene, is an integral component of the blood-brain barrier as an efflux pump for xenobiotics crucial in limiting drug uptake into the central nervous system. Dogs homozygous for a 4-base pair deletion of the canine MDR1 gene show altered expression or...

Author(s)
Mizukami, K.; Chang HyeSook; Yabuki, A.; Kawamichi, T.; Hossain, M. A.; Rahman, M. M.; Uddin, M. M.; Yamato, O.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2012, 24, 1, pp 127-134