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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

P-glycoprotein, encoded by the MDR1 or ABCB1 gene, is an integral component of the blood-brain barrier as an efflux pump for xenobiotics crucial in limiting drug uptake into the central nervous system. Dogs homozygous for a 4-base pair deletion of the canine MDR1 gene show altered expression or...

Author(s)
Mizukami, K.; Chang HyeSook; Yabuki, A.; Kawamichi, T.; Hossain, M. A.; Rahman, M. M.; Uddin, M. M.; Yamato, O.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2012, 24, 1, pp 127-134
Abstract

Neuronal ceroid lipofuscinosis (NCL) constitutes a group of recessively inherited lysosomal storage diseases that primarily affect neuronal cells. Such diseases share certain clinical and pathologic features in human beings and animals. Neuronal ceroid lipofuscinosis in Border Collie dogs was first ...

Author(s)
Mizukami, K.; Chang HyeSook; Yabuki, A.; Kawamichi, T.; Kawahara, N.; Hayashi, D.; Hossain, M. A.; Rahman, M. M.; Uddin, M. M.; Yamato, O.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2011, 23, 6, pp 1131-1139
Abstract

Trapped neutrophil syndrome is an autosomal recessive inherited neutropenia in Border collies. The causative mutation is a 4 base pair deletion in exon 19 of the canine VPS13B gene. In this study, a real-time PCR assay was developed and a genotyping survey was carried out in Border collies in...

Author(s)
Mizukami, K.; Yabuki, A.; Kawamichi, T.; Chang HyeSook; Rahman, M. M.; Uddin, M. M.; Kohyama, M.; Yamato, O.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2013, 195, 2, pp 260-261
Abstract

Collie eye anomaly (CEA) is a canine inherited ocular disease that shows a wide variety of manifestations and severity of clinical lesions. Recently, a CEA-associated mutation was reported, and a DNA test that uses conventional polymerase chain reaction (PCR) has now become available. The objective ...

Author(s)
Chang HyeSook; Mizukami, K.; Yabuki, A.; Hossain, M. A.; Rahman, M. M.; Uddin, M. M.; Arai, T.; Yamato, O.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2010, 22, 5, pp 708-715