Dogs with pulmonary hypertension following administration of thiacetarsamide adulticide for Dirofilaria immitis infection were given antihistamine treatment under anaesthesia. Neither diphenhydramine (an H1 blocker) nor cimetidine (an H2 blocker) reduced pulmonary arterial pressure (P_PA) at...

Seventeen dogs with naturally acquired infections of D. immitis were studied before and after thiacetarsamide treatment, using physical examinations, arterial blood gas analyses, thoracic radiography, and pulmonary haemodynamic and arteriographic tests. Eight dogs were considered to have a low...

Because melarsomine dihydrochloride (RM340) has been shown to be more effective in killing D. immitis than the traditional approved adulticide, thiacetarsamide, an attempt was made to determine whether this new adulticide induced more severe lung disease. Before adulticide treatment, 32 dogs with...

Twelve dogs were infused with 10¹⁰Escherichia coli/kg of body weight through a portal vein catheter over a 1-hour period; 6 dogs were treated with flunixin meglumine (1 mg/kg) 15 minutes after the infusion had begun. Six dogs (controls) were infused with a comparable volume of sterile saline...

Pulmonary hypertension associated with myointimal proliferation develops in chronic Dirofilaria immitis infection. This study correlated changes in pulmonary artery haemodynamics and arteriograms with vascular alterations examined with scanning and light microscopy (SEM, LM) during infection and...

Heartworm disease Dirofilaria immitis in dogs is an infectious disease that produces pulmonary hypertension. Dogs with the early vascular changes of heartworm disease, but without the clinical cardiopulmonary signs and pulmonary hypertension, were studied. Dogs with early heartworm were identified...

Seven dogs were inoculated s/c with 50 infective D. immitis larvae and treated with arsenamide, dithiazinine iodide and tetramisole 12 months later. Cardiopulmonary function was measured before and 6 and 12 months after infection and 7 and 12 months after treatment. Pulmonary hypertension (26.4...

Clinical, haematological, arteriographical, radiographical, and morphological responses to dying heartworms were characterized in seven infected Beagles after arsenamide therapy. The Beagles, infected 27 or 31 months previously with 99 or 100 infective D. immitis (DI) larvae, had DI-induced...

Cardiopulmonary function in Beagles that had been infected 18 months previously with 100 infective Dirofilaria immitis larvae was studied before and after an exercise programme. The treadmill exercise programme lasted for 2.5 months at 5 days/week until the dogs were running for 20 min at 11.3 km/h ...

The ability of aspirin to block arteriosclerosis during chronic, low-level injury to pulmonary arteries was studied in 3 groups of 7 dogs after injury produced by the transplantation of 28 adult D. immitis into each dog. Control group A received no treatment; group B received no treatment for 6...