This study was undertaken to determine whether the angiotensin converting enzyme inhibitor, enalapril, would lower systemic arterial and glomerular capillary pressure and reduce the magnitude of renal injury in a canine model of renal insufficiency. 18 adult dogs that had renal mass reduced by...

Mixed-breed dogs of both sexes were parathyroidectomized [PTX] or had sham surgery. After surgical reduction of renal mass and PTX, 13 PTX dogs and 13 sham dogs were selected for a 24-month period of study and monitored for clinical, haematological, blood biochemical, and organ function status. On...

The pathology and treatment of progressive renal disease in dogs and cats is reviewed. Recently, the hypothesis that all renal diseases are inherently progressive and self-perpetuating has focused attention on adaptive changes in renal structure and function that occur whenever renal function is...

Single nephron adaptations to partial nephrectomy (Nx) in dogs and the effect of dietary protein restriction on these adaptations were studied. Results of micropuncture studies in partially Nx dogs indicated that remnant nephrons of dogs exhibit glomerular hyperfiltration (single nephron glomerular ...