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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

Objective: To determine the effects of fluconazole on oral methadone pharmacokinetics and central effects mediated by opioid receptors in dogs. Study design: Prospective, incomplete block. Animals: A total of 12 healthy Beagle dogs. Methods: Dogs were randomly allocated into two groups of six dogs. ...

Author(s)
KuKanich, B.; KuKanich, K.; Rankin, D.; Locuson, C. W.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2019, 46, 4, pp 501-509
Abstract

Tramadol is administered to dogs for analgesia but has variability in its extent of absorption, which may hinder its efficacy. Additionally, the active opioid metabolite (M1) occurs in low concentrations. The purpose of this study was to determine if administration of oral tramadol with suspected...

Author(s)
KuKanich, B.; KuKanich, K.; Black, J.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 6, pp e54-e61
Abstract

Fentanyl is a potent mu opioid receptor agonist that was discovered to identify an improved human health analgesic over morphine, an opioid frequently associated with histamine-release, bradycardia, hyper- or hypotension, and prolonged postoperative respiratory depression. Historically, the...

Author(s)
Kukanich, B.; Clark, T. P.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2012, 35, s2, pp 3-19