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Study suggests that even racehorses without respiratory signs could have inflammatory airway disease

Date
25 April 2018
Abstract

Macrophages and neutrophils are important cellular components in the process of acute inflammation and its subsequent resolution, and evidence increasingly suggests that they play important functions during the resolution of chronic, adaptive inflammatory processes. Exacerbated neutrophil activity...

Author(s)
Olave, C.; Morales, N.; Uberti, B.; Henriquez, C.; Sarmiento, J.; Ortloff, A.; Folch, H.; Moran, G.
Publisher
Springer, Dordrecht, Netherlands
Citation
Veterinary Research Communications, 2018, 42, 1, pp 57-63
Abstract

Severe equine asthma, formerly recurrent airway obstruction (RAO), is the horse counterpart of human asthma, affecting horses maintained indoors in continental climates. Equine pasture asthma, formerly summer pasture RAO, is clinically similar but affects grazing horses during hot, humid conditions ...

Author(s)
Ferrari, C. R.; Cooley, J.; Mujahid, N.; Costa, L. R.; Wills, R. W.; Johnson, M. E.; Swiderski, C. E.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2018, 55, 1, pp 144-158
AbstractFull Text

Clinical examination, bronchoalveolar lavage fluid (BALF) cytology, acute-phase protein, and pulmonary hemostasis and fibrinolysis marker (fibrinogen, serum amyloid A [SAA], and D-dimer) results were compared between control and respiratory disease-affected horses. Using a clinical scoring system, ...

Author(s)
Barton, A. K.; Wirth, C.; Bondzio, A.; Einspanier, R.; Gehlen, H.
Publisher
Korean Society of Veterinary Science, Seoul, Korea Republic
Citation
Journal of Veterinary Science, 2017, 18, 3, pp 349-357
Abstract

The delivery of drugs to horses via the inhalation route is being increasingly adopted as a therapeutic approach in equine practice; predominantly used to treat equine lower airway disease, including, but not restricted to, severe and mild to moderate equine asthma (previously termed recurrent...

Author(s)
Pirie, R. S.; McGorum, B. C.
Publisher
BMJ Publishing Group, London, UK
Citation
In Practice, 2017, 39, 7, pp 317...327
Abstract

Severe equine asthma (EA) is the newly adopted term which defines the syndromes most recently known as recurrent airway obstruction (RAO; syn chronic obstructive pulmonary disease, Heaves) or summer pasture associated recurrent airway obstruction (SPARAO; syn summer pasture associated obstructive...

Author(s)
Pirie, R. S.
Publisher
MA Healthcare Limited, London, UK
Citation
Livestock, 2017, 22, 4, pp 208-215
Abstract

Bronchial hyper-responsiveness (BHR) describes a lung abnormality in which airways are easily triggered to constrict in response to normally harmless inhaled stimuli, and is a key element of human asthma pathophysiology. BHR contributes to equine respiratory diseases including inflammatory airway...

Author(s)
Swiderski, C. E.; Hunter, C. L.; Bowser, J. E.; Costa, L. R.; Cooley, A. J.; Claude, A.; Eddy, A. L.; Bright, L. A.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2017, 52, pp 29-35
Abstract

Mild to moderate equine asthma (EA) is the newly adopted term which defines the syndrome previously known as inflammatory airway disease (IAD). The adoption of this new nomenclature recognises the clinical phenotypic overlap amongst various non-infectious diseases of the equine lower airways; most...

Author(s)
Pirie, R. S.
Publisher
MA Healthcare Limited, London, UK
Citation
Livestock, 2017, 22, 3, pp 158-163
Abstract

OBJECTIVE: To develop a method to maintain the initial phenotype of airway smooth muscle (ASM) cells isolated from equine endobronchial biopsy specimens in long-term cell culture. SAMPLE: Endobronchial tissue specimens (8 to 10/horse) collected from the lungs of previously healthy horses at...

Author(s)
Vargas, A.; Peltier, A.; Dubé, J.; Lefebvre-Lavoie, J.; Moulin, V.; Goulet, F.; Lavoie, J. P.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2017, 78, 3, pp 359-370
Abstract

OBJECTIVE: To evaluate the influence of respiratory tract disease (ie, recurrent airway obstruction [RAO]) and mode of inhalation on detectability of inhaled budesonide in equine plasma and urine samples. ANIMALS: 16 horses (8 healthy control horses and 8 horses affected by RAO, as determined by...

Author(s)
Barton, A. K.; Schenk, H. H. I.; Machnik, M.; Gehlen, H.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2017, 78, 2, pp 244-250

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