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Abstract

In horses, immune - mediated muscle disorders can arise from an overzealous immune response to concurrent infections or potentially from an inherent immune response to host muscle antigens. Streptococcus equi ss. equi infection or vaccination can result in infarctive purpura hemorrhagica (IPH) in...

Author(s)
Durward-Akhurst, S. A.; Valberg, S. J.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2018, 55, 1, pp 68-75
Abstract

Immune - mediated skin diseases, with the exemption of hypersensitivity disorders, are relatively uncommon conditions. The immune system protects the body from external threats by distinguishing self from non-self and attacking foreign antigens. Immunosuppressive treatments are therefore used to...

Author(s)
Neuber, A.; Nuttall, T.
Publisher
John Wiley & Sons, Chichester, UK
Citation
Diagnostic techniques in veterinary dermatology, 2017, pp 159-172
Abstract

Immune mediated keratitis (IMMK) is primarily a non-ulcerative keratitis in horses causing intermittent ocular pain, eventually resulting in visual impairment. Affected horses typically respond to immunomodulatory treatment. However, the underlying cause of the disease remains enigmatic. The...

Author(s)
Braus, B. K.; Miller, I.; Kummer, S.; Kleinwort, K. J. H.; Hirmer, S.; Hauck, S. M.; McMullen, R. J., Jr.; Kerschbaumer, M.; Deeg, C. A.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2017, 187, pp 48-54
Abstract

In this report, a ten-year-old gelding with immune - mediated hemolytic anemia associated with chronic fibrosing mediastinitis of unknown origin is described. The patient suffered from chronic weight loss and intermittent diarrhea for already several months. He was presented with severe anemia,...

Author(s)
Ribonnet, C.; Saey, V.; Ducatelle, R.; Palmers, K.
Publisher
Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium
Citation
Vlaams Diergeneeskundig Tijdschrift, 2019, 88, 5, pp 278-286
Abstract

Equine immune - mediated keratitis (IMMK) leads to increased corneal opacity and inflammation secondary to an alteration of the local immune system. Bone marrow-derived mesenchymal stem cells (BM-MSC) have been shown to modulate the immune system by downregulating inflammation. Four horses with...

Author(s)
Davis, A. B.; Schnabel, L. V.; Gilger, B. C.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2019, 22, 5, pp 674-682
Abstract

Immune mediated infertility was first reported in stallions in the 1990s. Dysregulation of the tolerogenic testicular environment leads to development of autoimmune orchitis (AO), defined as an autoimmune reaction to germ cell and sperm antigens. AO is characterized by testicular interstitial...

Author(s)
Ferrer, M.
Publisher
The Society for Theriogenology, Montgomery, USA
Citation
Clinical Theriogenology, 2019, 11, 3, pp 361-367
Abstract

Polyneuritis equi is an immune - mediated neurodegenerative condition in horses that is related to circulating demyelinating antibodies against equine myelin basic protein 2 (MP2). The present study examined the presence of circulating demyelinating antibodies against neuritogenic peptides of MP2...

Author(s)
Ellison, S. P.; Kennedy, T. J.; Li, A.
Publisher
Veterinary Solutions LLC, Apopka, USA
Citation
International Journal of Applied Research in Veterinary Medicine, 2015, 13, 3, pp 175-181
Abstract

Background: Major histocompatibility complex (MHC) I and II expression is not normally detected on sarcolemma, but is detected with lymphocytic infiltrates in immune - mediated myositis (IMM) of humans and dogs and in dysferlin-deficient muscular dystrophy. Hypothesis/Objectives: To determine if...

Author(s)
Durward-Akhurst, S. A.; Finno, C. J.; Barnes, N.; Shivers, J.; Guo, L. T.; Shelton, G. D.; Valberg, S. J.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2016, 30, 4, pp 1313-1321
Abstract

Objective: To describe the corneal in vivo confocal microscopy (IVCM) findings in horses with putative immune - mediated keratitis (IMMK). Animals: Sixty five horses with IMMK. Procedures: Horses diagnosed with IMMK were examined with a modified Heidelberg Retina Tomograph II and Rostock Cornea...

Author(s)
Ledbetter, E. C.; Irby, N. L.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2020, 23, 1, pp 4-15
Abstract

A 7-year-old Quarter Horse mare was presented for severe left hindlimb oedema and nonweightbearing lameness that was progressive over approximately 48 h. The mare subsequently developed marked and worsening oedema, immune - mediated haemolytic anaemia (IMHA), myositis and myocarditis. The marked...

Author(s)
Trimble, A. C.; Delph, K. M.; Beard, L. A.; Davis, E. G.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Education, 2019, 31, 5, pp 230-235

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