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Abstract

The purpose of this review is to present an up-to-date summary of the signs, diagnosis, treatment, and implications of equine hyperkalaemic periodic paralysis. The review encompasses all original articles published between 1986 and early 1993. Hyperkalaemic periodic paralysis is the result of a...

Author(s)
Naylor, J. M.
Citation
Canadian Veterinary Journal, 1994, 35, 5, pp 279-285
Abstract

Hyperkalemic periodic paralysis (HYPP) is an autosomal co-dominant genetic disease of Quarter-mile horses which originated by a point mutation of the gene coding the sodium channel protein in the plasmatic membrane of muscular cells. The mutation affects both dominant homozygous and heterozygous...

Author(s)
Riojas-Valdés, V.; Zamora-Ávila, D. E.; Hernández-Escareño, J. J.; Marroquín-Cardona, A.; Picón-Rubio, F. J.; Villarreal-Villarreal, J. P.; Ávalos-Ramírez, R.
Publisher
Academic Journals, Nairobi, Kenya
Citation
African Journal of Biotechnology, 2014, 13, 12, pp 1323-1326
Abstract

The aim of this paper was to present hyperkalemic periodic paralysis (HYPP), the disease caused by a genetic defect in sodium channel of skeletal muscles in horses. It is inherited as autosomal dominant trait with variable penetration. The abnormality in the sodium channel predisposes the horse to...

Author(s)
Wojtulewicz, P.; Gruszczyńska, J.; Siewruk, K.
Publisher
Krajowa Izba Lekarsko Weterynaryjna, Warszawa, Poland
Citation
Życie Weterynaryjne, 2011, 86, 3, pp 196-201
AbstractFull Text

Hyperkalemic Periodic Paralysis (HYPP) is one of the major dominant genetic diseases which affect Quarter horses (QH). The HYPP is caused by a point mutation in the SCN4A gene and despite the presence of HYPP in Brazilian QH, limited data on the disease prevalence are available. The aim of this...

Author(s)
Delfiol, D. J. Z.; Oliveira Filho, J. P. de; Battazza, A.; Souza, C. P. de; Badial, P. R.; Araujo Júnior, J. P.; Borges, A. S.
Publisher
Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, Brazil
Citation
Ciência Rural, 2015, 45, 5, pp 854-857
Abstract

Four Quarter Horses (1 stallion, 3 mares) with hyperkalaemic periodic paralysis were mated to unaffected horses to determine the genetic basis of the disease. The affected stallion was bred to 11 unaffected mares (4 Quarter Horses, 1 Arabian, 2 Standardbreds, and 4 Thoroughbreds). The 3 affected...

Author(s)
Spier, S. J.; Carlson, G. P.; Harrold, D.; Bowling, A.; Byrns, G.; Bernoco, D.
Citation
Journal of the American Veterinary Medical Association, 1993, 202, 6, pp 933-937
Abstract

History: A 3-year-old, 400 kg, gelding Quarter Horse was presented for investigation of epistaxis. Physical examination: The horse was bright, alert and responsive with rectal temperature, heart rate and respiration rate within normal limits. Management: During a second general anaesthetic for...

Author(s)
Pang, D. S. J.; Panizzi, L.; Paterson, J. M.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2011, 38, 2, pp 113-120
Abstract

Hyperkalaemic periodic paralysis (HYPP) is a relatively new genetic disease that, so far, appears to be confined to descendants of the American Quarter Horse Impressive, a stallion identified as the link between the pedigrees of all affected horses, and that predominantly affects Quarter Horses but ...

Author(s)
Diakakis, N.; Spanoudes, K.; Dessiris, A.
Publisher
Equine Veterinary Journal Ltd, Newmarket, UK
Citation
Equine Veterinary Education, 2008, 20, 8, pp 396-400
Abstract

Questionnaires were sent to owners, trainers or attending veterinarians of 189 horses testing homozygous for hyperkalaemic periodic paralysis (HPP) between October 1992 and November 1994. 69 (37%) questionnaires were completed and returned. Clinical episodes of muscle weakness or paralysis varied...

Author(s)
Carr, E. A.; Spier, S. J.; Kortz, G. D.; Hoffman, E. P.
Citation
Journal of the American Veterinary Medical Association, 1996, 209, 4, pp 798-803
Abstract

The contractile activity, the threshold for calcium-induced calcium release in fractions of sarcoplasmic reticulum and the potassium concentration were determined in preparations of semimembranosus muscle from 7 normal quarter horses and 7 quarter horses with hyperkalaemic periodic paralysis before ...

Author(s)
Beech, J.; Fletcher, J. E.; Tripolitis, L.; Lindborg, S.; Dawso, T.
Citation
Research in Veterinary Science, 1995, 58, 3, pp 206-211
Abstract

The pedigrees of 17 horses with hyperkalaemic paralysis were studied. All were first-, second-, or third-generation offspring of a common sire, 16 were registered Quarter Horses. Analysis indicated that it was unlikely that the concentration of hyperkalaemic periodic paralysis in the offspring of...

Author(s)
Naylor, J. M.; Robinson, J. A.; Bertone, J.
Citation
Journal of the American Veterinary Medical Association, 1992, 200, 3, pp 340-343

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