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Abstract

Varying susceptibility exists among mammalian species to the development of potentially fatal endotoxemia due to gram-negative bacteria molecular component, lipopolysaccharide (LPS). Toll-like receptor 4 (TLR4) is responsible for LPS-associated immune response and is expressed on numerous immune...

Author(s)
Hay, A. N.; Potter, A.; Kasmark, L.; Zhu Jing; Leeth, C. M.
Publisher
Oxford University Press, Cary, USA
Citation
Journal of Animal Science, 2019, 97, 5, pp 2175-2180
Abstract

Equine endotoxemia is a serious clinical problem with high mortality. Only a few treatments have been proved the therapeutic efficacy for equine endotoxemia. Excessive nuclear factor-kappa B (NF-κB) activation and production of proinflammatory cytokines, which were induced by reaction to...

Author(s)
Sato, H.; Matsuda, K.; Amagai, Y.; Tanaka, A.; Matsuda, H.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2018, 61, pp 114-120
Abstract

In comparison to other animal species the horse is very sensitive to the systemic consequences of endotoxemia leading to a high morbidity and mortality of gastrointestinal (e.g. colic or colitis) disease. Procalcitonin (PCT) is used in human medicine as a sensitive marker for the presence of a...

Author(s)
Teschner, D.; Rieger, M.; Koopmann, C.; Gehlen, H.
Publisher
Hippiatrika Verlag GmbH, Baden-Baden, Germany
Citation
Pferdeheilkunde, 2015, 31, 4, pp 371-377
Abstract

Endotoxemia models are used to study mechanisms and treatments of early sepsis. Repeated endotoxin exposures induce periods of endotoxin tolerance, characterized by diminished proinflammatory responses to lipopolysaccharide (LPS) and modulated production of proinflammatory cytokines. Repeated...

Author(s)
Holcombe, S. J.; Jacobs, C. C.; Cook, V. L.; Gandy, J. C.; Hauptman, J. G.; Sordillo, L. M.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2016, 173, pp 10-16
Abstract

Background: Continuous digital cryotherapy experimentally prevents development and reduces severity of sepsis-associated laminitis. A sleeve style ice boot where ice is in direct contact with the skin, and water drains from the boot is being used clinically for distal limb cryotherapy. The degree...

Author(s)
Burke, M. J.; Tomlinson, J. E.; Blikslager, A. T.; Johnson, A. L.; Dallap-Schaer, B. L.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2018, 50, 6, pp 848-853
Abstract

Horses with inflammatory diseases such as an acute abdominal crisis, enterocolitis, septic endometritis and pleuritis risk developing laminitis. This chapter presents medical therapeutic options for septic/endotoxic horses with presumptive acute developmental laminitis. The pathophysiology of...

Author(s)
Hurcombe, S. D.; Holcombe, S. J.
Publisher
John Wiley & Sons, Chichester, UK
Citation
Equine laminitis, 2017, pp 316-328
Abstract

Background: Hyperglycemia and endotoxemia have been associated with coagulation abnormalities in horses. Studies in humans suggest greater disturbances in coagulation with hyperglycemia and concurrent endotoxemia. Objectives: To compare coagulation parameters in horses administered with...

Author(s)
McGovern, K. F.; Lascola, K. M.; Smith, S. A.; Clark-Price, S. C.; Wilkins, P. A.; Schaeffer, D. J.; Foreman, J. H.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2013, 27, 2, pp 347-353
Abstract

Objective - To determine the effectiveness of preinduction hyperbaric oxygen treatment (HBOT) in ameliorating signs of experimentally induced endotoxemia in horses. Animals - 18 healthy adult horses. Procedures - Horses were randomly assigned to 1 of 3 equal-sized treatment groups to receive...

Author(s)
Baumwart, C. A.; Doherty, T. J.; Schumacher, J.; Willis, R. S.; Adair, H. S., III; Rohrbach, B. W.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2011, 72, 9, pp 1266-1275
Abstract

Reasons for performing study: Clinically useful biomarkers are needed for early identification of endotoxaemic horses. Soluble CD14 (sCD14) is amplified early in response to inflammatory signals, including bacterial lipopolysaccharide (LPS), and may prove a useful biomarker for clinical...

Author(s)
Fogle, J.; Jacob, M.; Blikslager, A.; Edwards, A.; Wagner, B.; Dean, K.; Fogle, C.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2017, 49, 2, pp 155-159
Abstract

Endotoxemia causes significant mortality and morbidity in horses. The mechanisms underlying this complex pathophysiology remain unclear. Therefore, effective tools to treat endotoxemia in horses are lacking. Furthermore, the multifactorial and multiorgan pathophysiology of equine endotoxemia has...

Author(s)
Aharonson-Raz, K.; Baljit Singh
Publisher
Canadian Veterinary Medical Association, Ottawa, Canada
Citation
Canadian Journal of Veterinary Research, 2010, 74, 1, pp 45-49

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