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Abstract

Background: Endocrine disorders are common in donkeys. Pituitary pars intermedia dysfunction (PPID) is thought to be a frequent disturbance in donkeys due to their longevity. However, information on PPID dynamic testing in donkeys is lacking. Objectives: The objective of this study was to evaluate...

Author(s)
Mejia-Pereira, S.; Perez-Ecija, A.; Buchanan, B. R.; Toribio, R. E.; Mendoza, F. J.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 4, pp 481-488
Abstract

Background: The thyrotropin-releasing hormone (TRH) stimulation test and the 2-step insulin sensitivity test are commonly used methods to diagnose, respectively, pituitary pars intermedia dysfunction (PPID) and insulin dysregulation (ID). Objectives: To investigate the diagnostic value of combining ...

Author(s)
Horn, R.; Bertin, F. R.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 5, pp 2249-2256
Abstract

Pituitary pars intermedia dysfunction (PPID) is a slowly progressive neurodegenerative disease of the horse. Diagnosis of PPID is based on the signalment, clinical signs and further diagnostic test results. The condition is seen in older animals - the average age of affected animals is 18 to 23...

Author(s)
Menzies-Gow, N.
Publisher
Veterinary Business Development Ltd, Peterborough, UK
Citation
Veterinary Times, 2019, 49, 23, pp 6-8
Abstract

Objective - To compare endogenous ACTH and α-melanocyte-stimulating hormone (α-MSH) concentrations after administration of thyrotropin-releasing hormone (TRH) and to compare ACTH concentrations after TRH administration with those following domperidone administration in healthy horses and horses...

Author(s)
Beech, J.; McFarlane, D.; Lindborg, S.; Sojka, J. E.; Boston, R. C.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2011, 238, 10, pp 1305-1315
Abstract

Published information on the pharmacokinetic and pharmacodynamic properties of pergolide is limited. The aim of this study was to investigate the pharmacokinetic and pharmacodynamic properties of oral pergolide in horses with pituitary pars intermedia dysfunction (PPID). The study design was a...

Author(s)
Rendle, D. I.; Doran, G.; Ireland, J.; Edwards, S.
Publisher
Elsevier Inc, New York, USA
Citation
Domestic Animal Endocrinology, 2019, 68, pp 135-141
Abstract

Background: Pituitary pars intermedia dysfunction (PPID) is a commonly described endocrine disorder in higher latitudes of the Northern hemisphere but the description of the disease at lower latitudes and in the Southern hemisphere is limited. Objectives: Document the clinical features of PPID at...

Author(s)
Horn, R.; Bamford, N. J.; Afonso, T.; Sutherland, M.; Buckerfield, J.; Tan, R. H. H.; Secombe, C. J.; Stewart, A. J.; Bertin, F. R.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 4, pp 440-445
Abstract

Thyrotropin releasing hormone (TRH)-stimulation testing for pituitary pars intermedia dysfunction (PPID) in horses is only recommended at certain times of the year. Current diagnostic cut-off values reflect testing in the northern hemisphere during this time. The aims of this study were to evaluate ...

Author(s)
Byrne, D. P.; Secombe, C. J.; Tan, R. H. H.; Perera, D. I.; Watts, S. P.; Wearn, J. G.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2018, 238, pp 58-62
Abstract

Similarly to aged humans, senior horses (≥20 years) exhibit chronic low-grade inflammation systemically, known as inflamm-aging. Inflamm-aging in the senior horse has been characterized by increased circulating inflammatory cytokines as well as increased inflammatory cytokine production by...

Author(s)
Siard-Altman, M. H.; Harris, P. A.; Moffett-Krotky, A. D.; Ireland, J. L.; Betancourt, A.; Barker, V. D.; McMurry, K. E.; Reedy, S. E.; Adams, A. A.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2020, 221,
Abstract

Pituitary pars intermedia dysfunction (PPID) used to be known as Cushing's disease. The anatomy and physiology of the hypophysis [pituitary] are described, as well as the pathophysiology and epidemiology of PPID in older horses. Symptoms are described and several test methods (dynamic and basal)...

Author(s)
Broux, B.; Lefere, L.; Loon, G. van
Publisher
Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium
Citation
Vlaams Diergeneeskundig Tijdschrift, 2013, 82, 1, pp 44-50
Abstract

Background: In dogs, spontaneous Cushing's syndrome is most often pituitary-dependent and caused by hypersecretion of adrenocorticotropic hormone (ACTH), resulting in increased adrenocortical glucocorticoid secretion similar to horses. In horses with Cushing's syndrome (or pituitary pars intermedia ...

Author(s)
Pijnacker, T.; Knies, M.; Galac, S.; Sanders, K.; Mol, J. A.; Kooistra, H. S.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Veterinary Quarterly, 2018, 38, 1, pp 72-78

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