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Abstract

Scientific information on spontaneous type I diabetes mellitus (DM) and treatment modalities in guinea pigs is scarce. As most diabetic guinea pigs are overweight and respond to dietary changes, a disorder resembling type II-DM in humans seems to be most prevalent in this species. In the present...

Author(s)
Kreilmeier-Berger, T.; Zeugswetter, F. K.; Blohm, K. O.; Schwendenwein, I.; Baszler, E.; Ploderer, B.; Burgener, I. A.; Künzel, F.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2021, 11, 4,
Abstract

Type 2 diabetes is a leading cause of morbidity and mortality among noncommunicable diseases, and additional animal models that more closely replicate the pathogenesis of human type 2 diabetes are needed. The goal of this study was to develop a model of type 2 diabetes in guinea pigs, in which...

Author(s)
Podell, B. K.; Ackart, D. F.; Richardson, M. A.; DiLisio, J. E.; Pulford, B.; Basaraba, R. J.
Publisher
Company of Biologists Ltd, Cambridge, UK
Citation
Disease Models & Mechanisms, 2017, 10, 2, pp 151-162
Abstract

Guinea pigs are useful animal models for the study of many human diseases including diabetes mellitus and infectious diseases. Often, these studies involve collecting blood samples of considerable volume. This column describes safe techniques for restraint and blood collection from the jugular vein ...

Author(s)
Williams, W. R.; Kendall, L. V.
Publisher
Nature America, Inc., New York, USA
Citation
Lab Animal, 2015, 44, 6, pp 207-208
Abstract

The aim of this paper is to investigate the effects of ghrelin on delayed gastrointestinal transit in streptozotocin-induced diabetic guinea pigs. A diabetic guinea pig model was produced by intraperitoneal (i. p.) injection of streptozotocin (STZ, 280 mg/kg). Diabetic guinea pigs were randomized...

Author(s)
Qiu WenCai; Yang ChengGuang; Yan Jun; Wang ZhiGang; Zheng Qi
Publisher
Academic Journals, Nairobi, Kenya
Citation
African Journal of Pharmacy and Pharmacology, 2012, 6, 10, pp 702-707
Abstract

Background: Whether there is a dose-dependent effect of maternal dietary cholecalciferol during pregnancy on maternal glucose tolerance is unknown. In addition, circulating osteocalcin is increased by 1,25-dihydroxyvitamin D [1,25(OH)2D] and may improve glucose homeostasis. Objective: This study...

Author(s)
Tabatabaei, N.; Rodd, C. J.; Kremer, R.; Weiler, H. A.
Publisher
American Society for Nutrition, Bethesda, USA
Citation
Journal of Nutrition, 2014, 144, 12, pp 1994-2001
Abstract

The objective of present study is to evaluate the antihistaminic activity of Benincasa hispida (Thunb.) Cogn. Commonly known as ash gourd belonging to Cucurbitaceae family, is employed as a main ingredient in Kusmanda lehyam in Ayurvedic system of medicine, has been used in India for centuries for...

Author(s)
Kanakam Vijayabhaskar; Puram Paramesh
Publisher
World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS), Sofia, Bulgaria
Citation
World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS), 2015, 4, 7, pp 751-760
Abstract

In this manuscript we describe two closely related inbred guinea pig strains, maintained at the Central Animal Facility of the Hannover Medical School, which develop a Type 2 diabetes mellitus-like syndrome. Both strains are characterised by a high incidence of hyperglycaemia, early onset and...

Author(s)
Glage, S.; Kamino, K.; Jörns, A.; Hedrich, H. J.; Wedekind, D.
Publisher
Elsevier GmbH, Jena, Germany
Citation
Journal of Experimental Animal Science, 2007, 43, 4, pp 309-317
Abstract

Objective: The aim of this study was to determine the expression of SCF mRNA and SCF protein in the bladders of guinea pigs with diabetic cystopathy (DCP). This work also aims to explore the correlation and mechanisms between SCF gene expression and DCP. Methods: Sixty guinea pigs were divided...

Author(s)
Zhang ShaoFeng; Xie Sheng; Gan Wei; Luo MaoHua; Li YunFei
Publisher
Progress in Modern Biomedicine, Harbin, China
Citation
Progress in Modern Biomedicine, 2011, 11, 12, pp 2317-2320
Abstract

The extract obtained from the bovine milk (whey) is a natural product that has in its composition numerous bioactive compounds with curative potential, confirmed by the literature. The milk extract consists of about 93% water and 6.5% dry matter, from which the most important are lactose, proteins, ...

Author(s)
Dreancă, A. I.; Marcus, I.
Publisher
Asociația Generală a Medicilor Veterinari din România, București, Romania
Citation
Revista Română de Medicină Veterinară, 2016, 26, 1, pp 60-66
Abstract

Although current HBV vaccines have an outstanding record of safety and efficacy, reduced immunogenicity is a problem in those of older age, or having renal impairment or diabetes mellitus. In this study, we tested the ability of AdvaxTM adjuvant, a novel polysaccharide adjuvant based on delta...

Author(s)
Saade, F.; Honda-Okubo, Y.; Trec, S.; Petrovsky, N.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2013, 31, 15, pp 1999-2007

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