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Abstract

Introduction: The pathophysiology of heart failure involves activation of several neurohormonal systems including the renin-angiotensin-aldosterone system. The mineralocorticoid receptor antagonist spironolactone has been shown to be beneficial in humans and dogs with heart failure. The objective...

Author(s)
James, R.; Guillot, E.; Garelli-Paar, C.; Huxley, J.; Grassi, V.; Cobb, M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2018, 20, 1, pp 1-12
Abstract

There is a growing body of experimental and clinical evidence supporting mineralocorticoid receptor (MR) activation as a powerful mediator of renal damage in laboratory animals and humans. Multiple pathophysiological mechanisms are proposed, with the strongest evidence supporting...

Author(s)
Spencer, S.; Wheeler-Jones, C.; Elliott, J.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2020, 43, 3, pp 243-267
Abstract

Hyperaldosteronism results from the excessive secretion of aldosterone, a mineralocorticoid hormone produced in zona glomerulosa of the adrenal glands. This leads to the abnormality of electrolyte metabolism. In dogs, cats and humans, aldosteronism may be primary or secondary. In primary...

Author(s)
Gójska-Zygner, O.; Zygner, W.
Publisher
Krajowa Izba Lekarsko Weterynaryjna, Warszawa, Poland
Citation
Życie Weterynaryjne, 2019, 94, 2, pp 134-141
Abstract

Primary hyperaldosteronism is a disease in which tumors or hyperplasias in the zona glomerulosa of the adrenal gland induce hypersecretion of aldosterone. Effects are thus consistent with the actions of aldosterone in the body: increased sodium retention, increase of blood volume and increased...

Author(s)
Padin, B. R.; Horta, P. V. P.
Publisher
Editora Guará, São Paulo, Brazil
Citation
Clínica Veterinária, 2017, 22, 127, pp 52-62
AbstractFull Text

Author(s)
Atkins, C.
Publisher
ASIS Biomedia s.l., Zaragoza, Spain
Citation
Argos - Informativo Veterinario, 2018, No.196, pp 10-11
Abstract

Author(s)
Ames, M. K.; Atkins, C. E.
Publisher
Eastern States Veterinary Association, Inc (NAVC), Glen Mills, USA
Citation
Today's Veterinary Practice, 2016, 6, 3, pp 87-92
Abstract

Background: Myocardial fibrosis occurs in cats with hypertrophic cardiomyopathy (HCM), and is one factor that leads to diastolic dysfunction. Spironolactone (SPIR) reduces myocardial fibrosis in several models of HCM and in humans with cardiac disease. Hypothesis: SPIR will improve diastolic...

Author(s)
MacDonald, K. A.; Kittleson, M. D.; Kass, P. H.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Internal Medicine, 2008, 22, 2, pp 335-341
Abstract

This article discusses the benefits and risks of diuretics in dogs and cats with mitral valve disease leading to the development of cardiac failure. The recommended dose of spironolactone, along with other diuretics and vasodilators againsts the development of cardiac fibrosis in dogs and cats with ...

Author(s)
Desfontis, J. C.
Publisher
Éditions du Point Vétérinaire, Maisons-Alfort, France
Citation
Point Vétérinaire, 2013, 44, 332 Part 1, pp 11
Abstract

Author(s)
Wilkinson, R.
Publisher
Veterinary Business Development Ltd, Peterborough, UK
Citation
Veterinary Times, 2015, 45, 14, pp 12-14
Abstract

A tight interaction between endocrine and immune systems takes place mainly due to the key role of head kidney in both hormone and cytokine secretion, particularly under stress situations in which the physiological response promotes the synthesis and release of stress hormones which may lead into...

Author(s)
Khansari, A. R.; Parra, D.; Reyes-López, F. E.; Tort, L.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
General and Comparative Endocrinology, 2017, 250, pp 122-135

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