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Abstract

This study aimed to investigate the biotransformation of cat liver microsomes in comparison to dogs and humans using a high throughput method with fluorescent substrates and classical inhibitors specific for certain isozymes of the human cytochrome P450 (CYP) enzyme family. The metabolic activities ...

Author(s)
Beusekom, C. D. van; Schipper, L.; Fink-Gremmels, J.
Publisher
Blackwell Publishing Ltd, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2010, 33, 6, pp 519-527
Abstract

Inhibitory effects of ketoconazole (KTZ), cimetidine (CIM), and erythromycin (ERY) were examined on CYP3A activities. Midazolam 1′- and 4-hydroxylation (MDZ1′H and MDZ4H) were used to determine CYP3A activities in hepatic microsomes obtained from cats (n=4). The results showed that, all the...

Author(s)
Shah, S. S.; Sasaki, K.; Hayashi, Y.; Motoyama, S.; Helmi, A. R.; Khalil, W. F.; Shimoda, M.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2009, 71, 9, pp 1151-1159
Abstract

In this study we examined activities of cytochrome P450 (CYP)1A, 2C, 2D and 3A using hepatic microsomes from five male and five female cats. CYP1A, 2C, 2D and 3A activities were referred by ethoxyresorufin O-deethylation (EROD), tolbutamide hydroxylation (TBH), bufuralol 1′-hydroxylation (BLH) and...

Author(s)
Shah, S. S.; Sanda, S.; Regmi, N. L.; Sasaki, K.; Shimoda, M.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2007, 30, 5, pp 422-428
AbstractFull Text

Author(s)
Kraus, M. S.
Publisher
North American Veterinary Conference, Gainesville, USA
Citation
Small Animal and Exotics Proceedings. North American Veterinary Conference, Orlando, Florida, USA, 19-23 January 2013., 2013, pp unpaginated
Abstract

Author(s)
Ozaki, H.; Nishimura, R.
Publisher
Buneido Publishing Company Ltd, Tokyo, Japan
Citation
Journal of Veterinary Medicine, Japan, 2001, 54, 6, pp 512-517
Abstract

Author(s)
Bhattacharyya, T. K.; Debnath, P. K.
Citation
Indian Journal of Experimental Biology, 1994, 32, 11, pp 786-788
Abstract

Ventricular preexcitation was diagnosed in 6 dogs and 7 cats examined because of weakness, syncope, or congestive heart failure, and as an incidental finding in 1 dog and 2 cats. Reciprocating tachycardias were documented in 8 of the cases. Six of the cats had a pathological diagnosis of primary...

Author(s)
Hill, B. L.; Tilley, L. P.
Citation
Journal of the American Veterinary Medical Association, 1985, 187, 10, pp 1026-1031
Abstract

The kinetics and concentrations of quinidine were determined in ponies, goats, pigs, dogs, and cats following intravenous administration. Plasma half-life values varied from 0.85 hours in goats to 5.59 hours in dogs. Quinidine attained distribution equilibrium very rapidly and was sequestered in...

Author(s)
Neff, C. A.; Davis, L. E.; Baggot, J. D.
Citation
American Journal of Veterinary Research, 1972, 33, No.7, pp 1521-1525
Abstract

Author(s)
Rick, A. de; Belpaire, F. M.; Bogaert, M. G.; Mattheeuws, D.; Chakrabarti, S.
Publisher
MTP Press Ltd., Lancaster, UK
Citation
Veterinary pharmacology and toxicology, 1983, pp 333-339
Abstract

Author(s)
Darke, P. G. G.
Citation
Veterinary Annual, 1986, 26, pp 195-201

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