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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

5-Fluorouracil is an antineoplastic drug with a narrow therapeutic window. Pets are commonly exposed to the cream used for pre-malignant and malignant skin lesions in humans. 5-Fluorouracil poisoning is characterised by severe gastrointestinal (vomiting; diarrhoea; and gastrointestinal ulceration...

Author(s)
Bates, N.
Publisher
MA Healthcare Limited, London, UK
Citation
Companion Animal, 2019, 24, 6, pp 288-292
Abstract

5-Fluorouracil (5-FU) is used in combination chemotherapy protocols for human head and neck cancer and other epithelial neoplasms. However, a paucity of literature describing use of this drug in veterinary oncology exists, likely due to previous reports of fatal neurotoxicity in both dogs and cats, ...

Author(s)
Menard, K.; Flesner, B. K.; Glahn, A.; Boudreaux, B.; Bryan, J. N.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 4, pp 590-595
Abstract

Blood circulates as a liquid containing cells and numerous chemicals; it functions to transport nutrients, chemicals, oxygen and waste products to and from cells, and is involved in defence and wound repair to tissues. Numerous toxic substances can disrupt the normal function of the blood through...

Author(s)
Bates, N.
Publisher
MA Healthcare Limited, London, UK
Citation
Companion Animal, 2020, 25, 6, pp 184-190
Abstract

Blood circulates as a liquid containing cells and numerous chemicals; it functions to transport nutrients, chemicals, oxygen and waste products to and from cells, and is involved in defence and wound repair to tissues. Numerous toxic substances can disrupt the normal function of the blood through...

Author(s)
Bates, N.
Publisher
MA Healthcare Limited, London, UK
Citation
The Veterinary Nurse, 2019, 10, 4, pp 196-203
Abstract

Nephrotoxicity is common with the use of the chemotherapeutic agent 5-Fluorouracil (5-FU). The current study aimed to investigate the probable protective effect of taurine (TAU) against 5-FU-induced nephrotoxicity in rats using biochemical, histological and ultrastructural approaches. Twenty-four...

Author(s)
Yousef, H. N.; Aboelwafa, H. R.
Publisher
Elsevier GmbH, München, Germany
Citation
Experimental and Toxicologic Pathology, 2017, 69, 5, pp 265-274
Abstract

Background: Colorectal cancer (CRC) is one of the most common causes of cancer-associated mortality in the world. Anti-tumor effect of curcumin has been shown in different cancers; however, the therapeutic potential of novel phytosomal curcumin, as well as the underlying molecular mechanism in CRC, ...

Author(s)
Moradi-Marjaneh, R.; Hassanian, S. M.; Rahmani, F.; Aghaee-Bakhtiari, S. H.; Avan, A.; Khazaei, M.
Publisher
Bentham Science Publishers, Sharjah, United Arab Emirates
Citation
Current Pharmaceutical Design, 2018, 24, 39, pp 4626-4638
Abstract

Author(s)
Benaryeh, B.
Publisher
Educational Concepts LLC, Tulsa, USA
Citation
NAVC Clinician's Brief, 2015, No.August, pp unpaginated
Abstract

Use of 5-fluoropyridimine antimetabolite drugs, specifically 5-fluorouracil (5-FU), has been discouraged in cats because of adverse events including neurotoxicity and death. Causes of toxicity have never been elucidated. In humans, toxicity has been associated with ineffective metabolism secondary...

Author(s)
Saba, C. F.; Schmiedt, C. W.; Freeman, K. G.; Edwards, G. L.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2013, 11, 4, pp 265-271
Abstract

The compound 5-fluorouracil (5-FU) is the first choice chemotherapeutic agent for the treatment of colorectal cancer (CRC), but intestinal mucositis is a primary limiting factor in anticancer therapy. There is currently no broadly effective targeted treatment to cure this side effect....

Author(s)
Wang CanHong; Yang ShuXian; Gao Li; Wang LiLi; Cao Li
Publisher
Royal Society of Chemistry, Cambridge, UK
Citation
Food and Function, 2018, 9, 5, pp 2695-2704
AbstractFull Text

Leptospirosis is endemic in Malaysia with Leptospira species extensively isolated from domestic and wild animals. Rats were found to be the principal maintenance hosts followed by cattle, pigs, and dogs. The objectives of this study were to isolate and identify Leptospira serovars circulating among ...

Author(s)
Benacer, D.; Thong, K. L.; Ooi, P. T.; Souris, M.; Lewis, J. W.; Ahmed, A. A.; Mohd Zain, S. N.
Publisher
Malaysian Society of Parasitology and Tropical Medicine, Kuala Lumpur, Malaysia
Citation
Tropical Biomedicine, 2017, 34, 1, pp 89-97

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