Different structurally related phenylpiperidine opioids exhibit different isoflurane-sparing effects in cats. Because minimum alveolar concentration (MAC) in cats is affected only by very high plasma concentrations of some phenylpiperidine opioids, we hypothesized these effects are caused by...

The aim of this study was to compare the pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats. Six adult cats were used. Anesthesia was induced and maintained with isoflurane in oxygen. End-tidal isoflurane concentration was set at 2% and adjusted as required due ...

Felines present peculiarities, among them the recognizement of pain is a big challenge for the clinical and surgical routine of veterinary medicine, as well the metabolism of some drugs in their bodies. This study's objective was to evaluate and compare the efficiency of two anesthetic protocols:...

Sixteen cats were used to compare the cardiovascular and anesthetic effects of remifentanil (REMI) or alfentanil (ALF) in propofol-anesthetized cats undergoing ovariohysterectomy. After premedication with acepromazine, anesthesia was induced and maintained with a constant rate infusion of propofol...

In animal health risk assessment, hazard characterisation of feed additives has been often using the default uncertainty factor (UF) of 100 to translate a no-observed-adverse-effect level in test species (rat, mouse, dog, rabbit) to a 'safe' level of chronic exposure in farm and companion animal...

The effect of incremental doses of alfentanil on isoflurane minimum alveolar concentration (MAC) was determined in 6 healthy spayed female cats. Cats were anaesthetized with isoflurane and arterial blood samples were collected for measuring gas tensions, pH and plasma alfentanil concentration and...

Objective: To determine the cardiorespiratory effects of an intravenous infusion of propofol alone or in association with fentanyl, alfentanil, or sufentanil in cats and, for each combination, the minimal infusion rate of propofol that would inhibit a response to noxious stimuli. Design: Randomized ...

Alfentanil (50 µg/kg) was administered i.v., over 1 min to 6 healthy cats. Blood samples were collected from a preplaced arterial catheter at 0.625, 1.25, 2.5, 5, 10, 15, 20, 30, 45, 60, 90, 120, 180, 240, 360, and 480 min after the end of the alfentanil injection. A radioimmunoassay technique was...

Six healthy female cats were anaesthetised with isoflurane and anaesthesia was maintained for 60 min at 1.3 isoflurane minimum alveolar concentration (MAC). A noxious stimulus was applied for 5 min before i.v. administration of alfentanil to achieve estimated plasma concentration of 500 ng/ml and...

Opioid derivatives are widely used in veterinary medicine for the provision of peri-operative pain relief. They are effective, safe and versatile analgesics with the potential to provide rapid onset analgesia after administration. They can be classed according to their receptor effects as full or...