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Abstract

Background: Prior studies have suggested that pimobendan is associated with several positive effects in cats, including improved survival in cats with congestive heart failure and improved left atrial function in research colony cats with hypertrophic cardiomyopathy (HCM) and normal cats. However,...

Author(s)
Oldach, M. S.; Ueda, Y.; Ontiveros, E. S.; Fousse, S. L.; Visser, L. C.; Stern, J. A.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2021, 17, 89, pp (23 February 2021)
AbstractFull Text

The aims of this study were to investigate the effects of repeated and multiple-dose pimobendan on cardiac systolic function and the correlations between changes in cardiac systolic function and plasma concentrations of pimobendan and O-desmethylpimobendan (ODMP). Five clinically healthy cats were...

Author(s)
Sugimoto, K.; Sugita, K.; Orito, K.; Fujii, Y.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2022, 12, 8,
Abstract

Background: Pimobendan has been shown to impart a significant survival benefit in cardiomyopathic cats who receive it as part of heart failure therapy. However, use of pimobendan remains controversial in cats with hypertrophic cardiomyopathy (HCM) due to lack of pharmacodynamic data for pimobendan...

Author(s)
Oldach, M. S.; Ueda, Y.; Ontiveros, E. S.; Fousse, S. L.; Harris, S. P.; Stern, J. A.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2019, 6, February, pp 15
Abstract

Background: Pimobendan is frequently used off-label for treatments of cats with congestive heart failure (CHF). Concern exists regarding the safety of pimobendan in cats with outflow tract obstruction (OTO). Objectives: In cats treated with pimobendan, incidence of adverse effects will not differ...

Author(s)
Ward, J. L.; Kussin, E. Z.; Tropf, M. A.; Tou, S. P.; Defrancesco, T. C.; Keene, B. W.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 6, pp 2211-2222
Abstract

Background: The benefits of pimobendan in the treatment of congestive heart failure (CHF) in cats with hypertrophic cardiomyopathy (HCM) have not been evaluated prospectively. Hypothesis/Objectives: To investigate the effects of pimobendan in cats with HCM and recent CHF and to identify possible...

Author(s)
Schober, K. E.; Rush, J. E.; Fuentes, V. L.; Glaus, T.; Summerfield, N. J.; Wright, K.; Lehmkuhl, L.; Wess, G.; Sayer, M. P.; Loureiro, J.; MacGregor, J.; Mohren, N.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2021, 35, 2, pp 789-800
Abstract

Objectives The objective of this study was to investigate the effect of pimobendan on echocardiographic parameters of right ventricular and atrial function in healthy cats. Animals Eleven privately owned, healthy adult cats. Material and methods Each cat underwent five echocardiographic...

Author(s)
Kost, L. V.; Glaus, T. M.; Diana, A.; Baron Toaldo, M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2021, 37, pp 52-61
Abstract

Introduction: The effects of pimobendan on the heart rhythm in cats are unknown. The purpose of this pilot study was to evaluate the effect of pimobendan on the cardiac rhythm and selected echocardiographic parameters of cats. Animals, materials, and methods: Six clinically healthy cats received...

Author(s)
Fujii, Y.; Sugimoto, K.; Omichi, M.; Kanai, K.; Orito, K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2021, 35, pp 74-83
Abstract

Objectives: - To evaluate the effect of a single dose of pimobendan on left atrial (LA) function in healthy cats. Animals - Eleven client owned healthy cats. Material and methods: - Standardized and repeated echocardiographic examinations were performed on healthy and conscious cats before and...

Author(s)
Baron Toaldo, M.; Pollesel, M.; Diana, A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2020, 28, pp 37-47
Abstract

Background: Arterial thromboembolism is a sequela of hypertrophic cardiomyopathy (HCM) in cats related to left atrial (LA) enlargement and dysfunction. Hypothesis: Pimobendan improves LA transport function in cats. Animals: Twenty-two client-owned cats with HCM and 11 healthy cats. Methods:...

Author(s)
Kochie, S. L.; Schober, K. E.; Rhinehart, J.; Winter, R. L.; Bonagura, J. D.; Showers, A.; Yildez, V.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 35, 1, pp 10-21
Abstract

OBJECTIVE: To determine the pharmacokinetics and potential adverse effects of pimobendan after oral administration in New Zealand White rabbits (Ocytolagus cuniculi). ANIMALS: 10 adult sexually intact (5 males and 5 females) rabbits. PROCEDURES: 2 pilot studies were performed with a pimobendan...

Author(s)
Ozawa, S. M.; Guzman, D. S. M.; Hawkins, M. G.; Diao, S. M.; Masri, A. E.; Gunther-Harrington, C. T.; Knych, H. K.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2022, 83, 4, pp 356-363

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