The aim of this study was to assess the effects of commonly used anaesthetics alfaxalone and propofol on salivary and urinary cortisol in healthy cats. Fifteen male castrated research-purposed cats received randomly intravenous continuous rate infusions of 8 mg/kg/h of alfaxalone, 12 mg/kg/h of...
Author(s)
Yozova, I. D.; Sano, H.; Weidgraaf, K.; Candy, E. J.; Cockrem, J. F.
Publisher
Elsevier Inc, New York, USA
Citation
Domestic Animal Endocrinology, 2021, 74,
OBJECTIVE: To investigate the effects of a priming dose of alfaxalone on the total anesthetic induction dose for and cardiorespiratory function of sedated healthy cats. ANIMALS8 healthy adult cats. PROCEDURESFor this crossover study, cats were sedated with dexmedetomidine and methadone administered ...
Author(s)
Lagos-Carvajal, A.; Queiroz-Williams, P.; Cremer, J.; Pereira, C. H. R.; Nevarez, J.; Cunha, A. F. da; Liu ChinChi
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2020, 81, 11, pp 850-855
Objective: To determine the effective plasma alfaxalone concentration for the production of immobility in cats. Study design: Prospective up-and-down study. Animals: Sixteen 1-2 year old male castrated research cats. Methods: Cats were instrumented with catheters in a jugular and a medial saphenous ...
Author(s)
Pypendop, B. H.; Siao, K. T.; Ranasinghe, M. G.; Pasloske, K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2018, 45, 3, pp 269-277
Objectives: The aim of this pilot study was to compare the quality of sedation and ease of intravenous (IV) catheter placement following sedation using two intramuscular (IM) sedation protocols in cats: hydromorphone, alfaxalone and midazolam vs hydromorphone and alfaxalone. Methods: This was a...
Author(s)
Wheeler, E. P.; Abelson, A. L.; Lindsey, J. C.; Wetmore, L. A.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2021, 23, 12, pp 1109-1116
Objectives: The aim of this study was to compare the quality of sedation with three different anaesthetic protocols (alfaxalone combined with butorphanol, methadone or pethidine) administered intramuscularly in cats, and to evaluate the influence of the injection site (between supraspinatus and...
Author(s)
Giannettoni, G.; Moretti, G.; Menchetti, L.; Pepe, A.; Bellocchi, F.; Bufalari, A.; Nannarone, S.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2022, 24, 8, pp e269-e280
Objective: To evaluate the effect of alfaxalone and methadone administered intramuscularly (IM), with or without ketamine, on sedation and echocardiographic measurements in healthy cats. Study design: A randomized, blinded, clinical study. Animals: A group of 24 client-owned cats. Methods: Baseline ...
Author(s)
Lazzarini, E.; Martinelli, E.; Brioschi, F. A.; Gioeni, D.; Corneliani, R. T.; Carotenuto, A. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2020, 47, 5, pp 621-630
To compare the anesthetic effects after intravenous administration of alfaxalone or propofol without premedication, either alfaxalone (5 mg/kg) or propofol (10 mg/kg) was administered intravenously over 120 sec in 6 cats. Each cat received the alternate treatment at least a 7-day interval....
Author(s)
Tamura, J.; Oyama, N.; Fukui, S.; Yamashita, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2021, 83, 1, pp 73-77
AIMS: To determine the pharmacokinetics, and anaesthetic and sedative effects of alfaxalone after I/V and I/M administration to cats. METHODS: Six European shorthair cats, three males and three females, with a mean weight of 4.21 (SD 0.53) kg and aged 3.8 (SD 0.9) years were enrolled in this...
Author(s)
Rodrigo-Mocholí, D.; Escudero, E.; Belda, E.; Laredo, F. G.; Hernandis, V.; Marín, P.
Publisher
Taylor & Francis, Melbourne, Australia
Citation
New Zealand Veterinary Journal, 2018, 66, 4, pp 172-177
The article describes the injectable anesthetic alfaxalone and its use in dogs and cats. It is a relatively safe drug suitable for high-risk patients. Alfaxalon can be administered intravenously, intramuscularly or subcutaneously. It has a relatively rapid metabolism and causes minimal...
Publisher
Profi Press, s.r.o., Prague, Czech Republic
Citation
Veterinářství, 2021, 71, 11, pp 623-626
A one-year-old captive black leopard (Panthera pardus) was evaluated for chronic lethargy, behavioural abnormalities and vomiting. The leopard was immobilised with intramuscular alfaxalone (Alfaxan; 1.6 mg/kg) and ketamine (3.1 mg/kg) at doses similar to those used in domestic cats. General...
Author(s)
Jimenez, I. A.; Militana, E. A.; Martin-Flores, M.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2020, 8, 2,