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Abstract

The aim of this study was to assess the effects of commonly used anaesthetics alfaxalone and propofol on salivary and urinary cortisol in healthy cats. Fifteen male castrated research-purposed cats received randomly intravenous continuous rate infusions of 8 mg/kg/h of alfaxalone, 12 mg/kg/h of...

Author(s)
Yozova, I. D.; Sano, H.; Weidgraaf, K.; Candy, E. J.; Cockrem, J. F.
Publisher
Elsevier Inc, New York, USA
Citation
Domestic Animal Endocrinology, 2021, 74,
Abstract

OBJECTIVE: To investigate the effects of a priming dose of alfaxalone on the total anesthetic induction dose for and cardiorespiratory function of sedated healthy cats. ANIMALS8 healthy adult cats. PROCEDURESFor this crossover study, cats were sedated with dexmedetomidine and methadone administered ...

Author(s)
Lagos-Carvajal, A.; Queiroz-Williams, P.; Cremer, J.; Pereira, C. H. R.; Nevarez, J.; Cunha, A. F. da; Liu ChinChi
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2020, 81, 11, pp 850-855
Abstract

Objective: To determine the effective plasma alfaxalone concentration for the production of immobility in cats. Study design: Prospective up-and-down study. Animals: Sixteen 1-2 year old male castrated research cats. Methods: Cats were instrumented with catheters in a jugular and a medial saphenous ...

Author(s)
Pypendop, B. H.; Siao, K. T.; Ranasinghe, M. G.; Pasloske, K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2018, 45, 3, pp 269-277
Abstract

To compare the anesthetic effects after intravenous administration of alfaxalone or propofol without premedication, either alfaxalone (5 mg/kg) or propofol (10 mg/kg) was administered intravenously over 120 sec in 6 cats. Each cat received the alternate treatment at least a 7-day interval....

Author(s)
Tamura, J.; Oyama, N.; Fukui, S.; Yamashita, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2021, 83, 1, pp 73-77
Abstract

Objective: To characterize the hemodynamic effects of subclinical, clinical and supraclinical plasma alfaxalone concentrations in cats. Study design: Experimental study. Animals: A group of six adult healthy male neutered cats. Methods: Cats were anesthetized with desflurane in oxygen for...

Author(s)
Pypendop, B. H.; Barter, L. S.; Pascoe, P. J.; Ranasinghe, M. G.; Pasloske, K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2019, 46, 5, pp 597-604
Abstract

AIMS: To determine the pharmacokinetics, and anaesthetic and sedative effects of alfaxalone after I/V and I/M administration to cats. METHODS: Six European shorthair cats, three males and three females, with a mean weight of 4.21 (SD 0.53) kg and aged 3.8 (SD 0.9) years were enrolled in this...

Author(s)
Rodrigo-Mocholí, D.; Escudero, E.; Belda, E.; Laredo, F. G.; Hernandis, V.; Marín, P.
Publisher
Taylor & Francis, Melbourne, Australia
Citation
New Zealand Veterinary Journal, 2018, 66, 4, pp 172-177
Abstract

Objective: To evaluate the effect of alfaxalone and methadone administered intramuscularly (IM), with or without ketamine, on sedation and echocardiographic measurements in healthy cats. Study design: A randomized, blinded, clinical study. Animals: A group of 24 client-owned cats. Methods: Baseline ...

Author(s)
Lazzarini, E.; Martinelli, E.; Brioschi, F. A.; Gioeni, D.; Corneliani, R. T.; Carotenuto, A. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2020, 47, 5, pp 621-630
Abstract

AIM: To determine if cats anaesthetised with alfaxalone have different recoveries to cats anaesthetised with a combination of ketamine and diazepam. METHODS: Anaesthesia for ovariohysterectomy was induced in cats with either alfaxalone (n=23) or a combination of ketamine and diazepam (n=22). All ...

Author(s)
Gieseg, M. A.; Hon, H.; Bridges, J.; Walsh, V.
Publisher
Taylor & Francis, Melbourne, Australia
Citation
New Zealand Veterinary Journal, 2014, 62, 3, pp 103-109
Abstract

A one-year-old captive black leopard (Panthera pardus) was evaluated for chronic lethargy, behavioural abnormalities and vomiting. The leopard was immobilised with intramuscular alfaxalone (Alfaxan; 1.6 mg/kg) and ketamine (3.1 mg/kg) at doses similar to those used in domestic cats. General...

Author(s)
Jimenez, I. A.; Militana, E. A.; Martin-Flores, M.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2020, 8, 2,
Abstract

Objectives: To determine the context-sensitive half-time of alfaxalone following intravenous infusions of various durations. To estimate the time necessary for plasma concentration to decrease by up to 95%. Study design: Prospective randomized and simulation studies. Animals: A group of six...

Author(s)
Pypendop, B. H.; Ranasinghe, M. G.; Pasloske, K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2018, 45, 5, pp 630-639

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