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Abstract

Timolol maleate (TM), a beta-adrenergic receptor antagonist, is widely used for canine antiglaucoma eye drops; however, its bioavailability is <5%. Our previous study revealed that magnesium hydroxide nanoparticles (nMH) have potency in improving the bioavailability of fixed-combined TM in rodent models. This study aimed to investigate whether the fixed combination with nMH improves the ocular hypotensive effect of TM and affects pupil size (PS), heart rate (HR), and mean arterial pressure (MAP) in clinically healthy dogs. Five clinically healthy dogs were administered topical saline, commercial 0.5% TM, and a 0.01% or 0.1% nMH-0.5% TM fixed combination (0.01% or 0.1%...

Author(s)
Kita, M.; Kanai, K.; Mitsuhashi, H.; Noguchi, T.; Nagai, N.; Yamaguchi, M.; Otaka, Y.; Kudo, R.; Yamashita, Y.; Tajima, K.
Publisher
MDPI AG, Basel, Switzerland
Citation
Veterinary Sciences, 2021, 8, 8,
Abstract

2% dorzolamide, 0.5% timolol or 0.005% latanoprost contribute to decrease intraocular pressure (IOP) in the therapeutic management of human and canine glaucoma. As latanoprost induces myosis, we evaluated in this study the short-term effects of two other different hypotensive drugs on the anterior...

Author(s)
Poinsard, A. S.; Bastogne, T.; Balland, O.
Publisher
École Nationale Vétérinaire de Toulouse, Toulouse, France
Citation
Revue de Médecine Vétérinaire, 2018, 169, 11/12, pp 203-208
AbstractFull Text

This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed...

Author(s)
Dower, N. M. B.; Ribeiro, A. P.; Maciel, C. do E. S.; Spiller, P. R.; Monteiro, G. B.; Pizzinatto, F. D.; Yamauchi, K. C. I.
Publisher
Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, Brazil
Citation
Ciência Rural, 2017, 47, 9, pp e20160959
Abstract

Timolol maleate 0.5% is a drug recommended for glaucoma treatment in dogs. After administration, it is absorbed to systemic circulation and being an antagonist of beta adrenergic receptors it has important systemic side effects on cardiac electrical conduction. The present study evaluated the...

Author(s)
Santos, R. M.; Leite, C. R.; Monteiro, F. de O.; Abreu, M. B. de; Lessa, D. A. B.; Santos, O. J. dos
Publisher
Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil
Citation
Brazilian Journal of Veterinary Research and Animal Science, 2015, 52, 2, pp 112-119
AbstractFull Text

The objectives of new topical formulations for the treatment of glaucoma are to reduce the intraocular pressure (IOP) and minimize the occurrence of side effects. The aim of this study was to determine the effects of topical application of timolol maleate gel formulation 0.1% applied once daily, on ...

Author(s)
Pugliese, M.; Ragusa, M.; Niutta, P. P.; Passantino, A.
Publisher
Veterinarski Fakultet Sveučilišta u Zagrebu (Faculty of Veterinary Medicine, University of Zagreb), Zagreb, Croatia
Citation
Veterinarski Arhiv, 2018, 88, 3, pp 335-343
Abstract

Objective - To determine effects after topical administration of latanoprost, timolol, or a commercially available latanoprosttimolol combination twice daily on intraocular pressure (IOP), pupil size (PS), and heart rate (HR) in clinically normal dogs. Animals - 17 clinically normal dogs....

Author(s)
Smith, L. N.; Miller, P. E.; Felchle, L. M.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2010, 71, 9, pp 1055-1061
Abstract

Objectives: To determine the effect of 1% brinzolamide, 2% dorzolamide hydrochloride or combination 2% dorzolamide hydrochloride/0.5% timolol to delay the elevation of the intraocular pressure in second eyes of dogs with primary closed-angle glaucoma. Methods: Analysis of retrospectively collated...

Author(s)
Stavinohova, R.; Newton, J. R.; Busse, C.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Small Animal Practice, 2015, 56, 11, pp 662-666
Abstract

Objective: To describe a novel, minimally invasive method for re-establishing aqueous humor outflow in dogs with refractory glaucoma after fibrous encapsulation of their Ahmed drainage implants. Procedure: Three dogs (4 eyes) underwent trans-capsular implantation of an Alcon EX-PRESS® glaucoma...

Author(s)
Berkowski, W., Jr.; Michau, T.; Stine, J.; Plummer, C.; Sherwood, M. B.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2020, 24, s1, pp 199-206
AbstractFull Text

The aim of this study was to evaluate changes in intraocular pressure (IOP), pupil size (PS), blood pressure (BP), heart rate (HR), and ECG variables (Pms wave PmV, PR interval, QRS complex, RMV wave and QT intervals) over time during the instillation of 0.5% timolol, 0.5% levobunolol and 0.5%...

Author(s)
Padua, I. R. M.; Ribeiro, A. P.; Padua, P. P. M.; Guimarães, P. J.; Silva, M. L.; Piso, D. Y. T.; Martins, B.; Aldrovani, M.; Semolin, L. M. S.; Camacho, A. A.; Laus, J. L.
Publisher
FEPMVZ - Editora, Belo Horizonte, Brazil
Citation
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2016, 68, 3, pp 641-650
AbstractFull Text

The purpose of this study was to examine the effect of continuous release of an antiglaucomatous drug using osmotic pump compared with the effect of conventional eye drop. In group 1, one eye of each dog was treated with artificial tears. In group 2, the right eye was treated with a fixed...

Author(s)
Kim Jury; Kim MinSu
Publisher
Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan
Citation
Pakistan Veterinary Journal, 2015, 35, 2, pp 239-241

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