Background: The American Heartworm Society currently recommends the use of a monthly macrocyclic lactone, a 28-day course of 10 mg/kg doxycycline BID, and the 3-dose protocol of melarsomine dihydrochloride for the treatment of canine heartworm disease. Doxycycline is necessary for the reduction of...

Antimicrobial stewardship programs (ASPs) have been suggested to reduce antimicrobial resistance phenomena in veterinary medicine, as antibiotics are commonly used without microbiological confirmation. The aim of the present study is to design a specific working flow for a tailored antimicrobial...

Urinary tract infections (UTI) are one of the most frequent bacterial infections in both human and companion animals. Uropathogenic Escherichia coli (UPEC), is the most common bacterium isolated from canine, feline, and humans UTIs. The study aimed to investigate the occurrence of tetracycline...

Doxycycline has antiproliferative effects in human lymphoma cells and in murine xenografts. We hypothesized that doxycycline would decrease canine lymphoma cell viability and prospectively evaluated its clinical tolerability in client-owned dogs with spontaneous, nodal, multicentric, substage a,...

Canine ehrlichiosis is caused by Ehrlichia canis and transmitted by Rhipicephalus sanguineus. A nine month old male Dachshund dog weighing 8.5 Kg was presented to the TVCC, Bihar Veterinary College, Patna with complaint of pyrexia, anorexia, melena and tick infestation. Blood smear examination...

A study was conducted in 55 clinical cases of various dermatological disorders in dogs irrespective of age, sex and breed. Out of these dogs. 29 (52.73%) cases were found to be complicated with bacterial infections. A total of 43 bacterial isolates were obtained, among which Staphylococcus spp. was ...

Tetracyclines are antibiotics widely used in human and veterinary medicine. Effects on the immune system and inflammatory response, including effects on blood leukocytes proliferation and function and in cytokines synthesis, have been described. Chemically modified tetracyclines (CMT) have lost...

The emergence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) antimicrobial resistance and epidemic genetic lineages is posing a challenge in veterinary medicine due to the limited therapeutical options. MRSP has been identified as an important canine pyoderma pathogen. Thus, we...

Staphylococcus coagulans is among the three most frequent pathogens of canine pyoderma. Yet, studies on this species are scarce. Twenty-seven S. coagulans and one S. schleiferi, corresponding to all pyoderma-related isolations from these two species at two veterinary laboratories in Lisbon,...

Interferon-lambda (IFN-λ) is a type-III IFN and is considered a candidate of antiviral therapeutics. Although the antiviral effects of IFN-λ have been investigated in several studies, it has not been clinically approved as an antiviral agent. In this study, an adenoviral vector expression system...