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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

Advances in stem cell technology, including the use of induced pluripotent stem cells (iPSC) to produce neurons and glial cells, offer new hope for patients with neurological disease and injuries. Pet dogs with spinal cord injuries provide an important spontaneous animal model for evaluating new...

Author(s)
Chow, L.; McGrath, S.; Saldanha, C. de A.; Whalen, L. R.; Packer, R.; Dow, S.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2020, 6, November,
Abstract

Mesenchymal stem cells (MSCs) isolated from adipose tissue (adipose-derived stem cells [ADSCs]) are considered one of the most promising cell types for applications in regenerative medicine. However, the regenerative potency of ADSCs may vary because of heterogeneity. Long-term trypsin treatment...

Author(s)
Mitani, K.; Ito, Y.; Takene, Y.; Hatoya, S.; Sugiura, K.; Inaba, T.
Publisher
Mary Ann Liebert, Inc., New Rochelle, USA
Citation
Stem Cells and Development, 2021, 30, 6, pp 337-349
Abstract

Hepatocellular carcinoma (HCC) is the most common type of canine primary liver tumor; however, most chemotherapies against HCC are ineffective due to resistance to anticancer agents. Sphere-forming cells are considered to act as cancer stem cells for various types of solid tumors and have been...

Author(s)
Itoh, H.; Tani, K.; Sunahara, H.; Nakaichi, M.; Iseri, T.; Horikirizono, H.; Itamoto, K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2021, 139, pp 25-31
Abstract

Primordial germ cells (PGCs) have been described as precursors of gametes and provide a connection within generations, passing on the genome to the next generation. Failures in the formation of gametes/germ cells can compromise the maintenance and conservation of species. Most of the studies with...

Author(s)
Souza, A. F. de; Pieri, N. C. G.; Martins, D. dos S.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2021, 11, 3,
Abstract

Mesenchymal stem cells (MSCs) possess regenerative and immunomodulatory properties and can control the immune dysregulation that leads to β-cell destruction. Stem-cell transplantation could thus manage insulin-dependent diabetes mellitus (IDDM) in dogs. In this pilot study, we aimed to assess ...

Author(s)
Rhew SungYong; Park SuMin; Li Qiang; An JuHyun; Chae HyungKyu; Lee JungHwa; Ahn JinOk; Song WooJin; Youn HwaYoung
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2021, 83, 4, pp 592-600
Abstract

Background: Adipose tissue has recently gained attention as a source of mesenchymal stem cells (AdMSCs) for applications in treating degenerative joint disease in veterinary patients. This study aimed to quantify the stromal vascular fractions (SVFs) and colony forming units (CFU) of AdMSCs from...

Author(s)
Jifcovici, A.; Solano, M. A.; Fitzpatrick, N.; Findji, L.; Blunn, G.; Sanghani-Kerai, A.
Publisher
MDPI AG, Basel, Switzerland
Citation
Veterinary Sciences, 2021, 8, 2,
AbstractFull Text

BACKGROUND: Canine mammary gland cancers are the most prevalent malignancies in dogs. There are different challenges regarding management of these cancers in dogs and human, one hypothesis is related to small cellular subset of tumor mass called cancer stem cell. These cells are therapy resistant...

Author(s)
Marzban, H.; Sasani, F.
Publisher
Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Citation
Iranian Journal of Veterinary Medicine, 2020, 14, 3, pp 329-341
AbstractFull Text

Mesenchymal stem cells (MSCs) are multipotent, which is defined by their ability to self-renew while maintaining the capacity to differentiate into a certain number of cells, presumably from their own germinal layer. MSCs therapy is based on their anti-inflammatory, immunomodulatory...

Author(s)
Dias, I. E.; Cardoso, D. F.; Soares, C. S.; Barros, L. C.; Viegas, C. A.; Carvalho, P. P.; Dias, I. R.
Publisher
Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya
Citation
Open Veterinary Journal, 2021, 11, 2, pp 188-202
Abstract

Osteoarthritis challenges traditional therapies and remains a leading cause of lameness in older dogs. Regenerative medicine offers new strategies, typically involving the injection of autologous adipose-derived mesenchymal stem cells (MSCs). Conversely, allogenic MSCs are appealing candidates to...

Author(s)
Taguchi, T.; Borjesson, D. L.; Osmond, C.; Griffon, D. J.
Publisher
Mary Ann Liebert, Inc., New Rochelle, USA
Citation
Stem Cells and Development, 2019, 28, 23, pp 1562-1571
AbstractFull Text

Background: Recently, mesenchymal stem cells therapy has been performed in dogs, although the outcome is not always favorable. Objectives: To investigate the therapeutic efficacy of mesenchymal stem cells (MSCs) using dog leukocyte antigen (DLA) matching between the donor and recipient in vitro....

Author(s)
Wi Hayeon; Lee Seunghoon; Kim Youngim; No JinGu; Lee Poongyeon; Lee BoRam; Oh KeonBong; Hur TaiYoung; Ock, S. A.
Publisher
Korean Society of Veterinary Science, Seoul, Korea Republic
Citation
Journal of Veterinary Science, 2021, 22, 5,

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