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Abstract

Objectives: Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors for poorer prognosis will decrease...

Author(s)
Hezzell, M. J.; Boswood, A.; López-Alvarez, J.; Lötter, N.; Elliott, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2017, 19, 4, pp 325-338
Abstract

Hyperaldosteronism results from the excessive secretion of aldosterone, a mineralocorticoid hormone produced in zona glomerulosa of the adrenal glands. This leads to the abnormality of electrolyte metabolism. In dogs, cats and humans, aldosteronism may be primary or secondary. In primary...

Author(s)
Gójska-Zygner, O.; Zygner, W.
Publisher
Krajowa Izba Lekarsko Weterynaryjna, Warszawa, Poland
Citation
Życie Weterynaryjne, 2019, 94, 2, pp 134-141
Abstract

Introduction: The pathophysiology of heart failure involves activation of several neurohormonal systems including the renin-angiotensin-aldosterone system. The mineralocorticoid receptor antagonist spironolactone has been shown to be beneficial in humans and dogs with heart failure. The objective...

Author(s)
James, R.; Guillot, E.; Garelli-Paar, C.; Huxley, J.; Grassi, V.; Cobb, M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2018, 20, 1, pp 1-12
Abstract

Publisher
Elsevier Inc., Philadelphia, USA
Citation
Advances in Small Animal Medicine and Surgery, 2020, 33, 4, pp 3-4
Abstract

Introduction: Aldosterone breakthrough (ABT) is the condition in which angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers fail to effectively suppress the activity of the renin angiotensin aldosterone system. The objective of this study was to determine if ABT...

Author(s)
Ames, M. K.; Atkins, C. E.; Eriksson, A.; Hess, A. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Veterinary Cardiology, 2017, 19, 3, pp 218-227
Abstract

Background: Spironolactone treatment in humans is associated with an increased risk of hyperkalemia and renal dysfunction. Hypothesis: Dogs with cardiac disease treated with spironolactone, in addition to conventional therapy, are not at higher risk for adverse events (AEs) than those receiving...

Author(s)
Lefebvre, H. P.; Ollivier, E.; Atkins, C. E.; Combes, B.; Concordet, D.; Kaltsatos, V.; Baduel, L.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2013, 27, 5, pp 1083-1091
Abstract

An eight-month-old Labrador retriever presented with abdominal effusion. Abdominal ultrasonography revealed significant free fluid and a linear hyperechoic band surrounding the abdominal organs. CT showed the gastrointestinal organs to be located centrally, enclosed by a thin, hyperattenuating...

Author(s)
Isaac, I.; Carrera, I.; Martí, J.; Dibella, A.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2020, 8, 1,
Abstract

Background: The renin-angiotensin-aldosterone system (RAAS) is activated in humans with portal hypertension (PH) associated with liver disease. However, involvement of RAAS in dogs with intrahepatic PH is not clear. Objective: To measure plasma renin activity (PRA) and plasma aldosterone...

Author(s)
Sakamoto, Y.; Sakai, M.; Sato, K.; Watari, T.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 1, pp 139-144
Abstract

This work describes the pharmacodynamics and efficacy of spironolactone and benazepril in the treatment of heart diseases in dogs and humans.

Author(s)
Atkins, C.; Guillot, E.; Ovaert, P.; Larhantec, B.
Publisher
Ceva Animal Health Ltd., Amersham, UK
Citation
Benazepril - spironolactone: 10 years of research, 2016, pp 19 pp.
Abstract

Based on history, signalment, auscultation and radiographic examination, the suspected diagnosis of mitral valve endocardiosis can be made in dogs. However, radiological and echocardiographic examinations are necessary for the final diagnosis and can be used to differentiate between stages B1 and...

Author(s)
Hungerbühler, S. O.; Henrich, E.
Publisher
Schattauer GmbH, Stuttgart, Germany
Citation
Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 2017, 45, 6, pp 417-427

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