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Abstract

We previously showed that (+)-tramadol is metabolized in dog liver to (+)-M1 exclusively by CYP2D15 and to (+)-M2 by multiple CYPs, but primarily CYP2B11. However, (+)-M1 and (+)-M2 are further metabolized in dogs to (+)-M5, which is the major metabolite found in dog plasma and urine. In this...

Author(s)
Jimenez, T. E. P.; Mealey, K. L.; Schnider, D.; Grubb, T. L.; Greene, S. A.; Court, M. H.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2018, 41, 6, pp 815-824
AbstractFull Text

Thirty dogs with unexplained illness and weakness, negative for blood protozoan and/or rickettsial parasites were found suffering from atrial fibrillation/atrial flutter. Normal sinus 'P' wave was replaced by coarse or fine 'f' waves or comparatively large oscillations. There was no evidence of...

Author(s)
Varshney, J. P.; Deshmukh, V. V.; Chaudhary, P. S.
Publisher
Intas Pharmaceuticals Ltd, Ahmedabad, India
Citation
Intas Polivet, 2011, 12, 2, pp 271-273
Abstract

This study aimed to investigate the biotransformation of cat liver microsomes in comparison to dogs and humans using a high throughput method with fluorescent substrates and classical inhibitors specific for certain isozymes of the human cytochrome P450 (CYP) enzyme family. The metabolic activities ...

Author(s)
Beusekom, C. D. van; Schipper, L.; Fink-Gremmels, J.
Publisher
Blackwell Publishing Ltd, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2010, 33, 6, pp 519-527
AbstractFull Text

The aim of the present study was to detect preliminarily the capacity and capability of a modified electrometric method for use in the measurement of cholinesterase (ChE) activity in the blood of adult stray dogs. These values could be used for comparison with the values of cholinesterase (ChE)...

Author(s)
Alias, A. S.
Publisher
College of Veterinary Medicine, University of Mosul, Mosul, Iraq
Citation
Iraqi Journal of Veterinary Sciences, 2014, 28, 2, pp Ar153-Ar159
AbstractFull Text

The prevalence of cardiac arrhythmias was studied in the canine population of 20,000 reported during a period of four years to hospital. The prevalence of arrhythmias was recorded as 3.04%. The arrhythmias were grouped into three categories as sinus arrhythmia, abnormalities of impulse formation...

Author(s)
Varshney, J. P.; Prajwalita Sutaria; Deshmukh, V. V.; Chaudhary, P. S.
Publisher
Intas Pharmaceuticals Ltd, Ahmedabad, India
Citation
Intas Polivet, 2013, 14, 1, pp 129-136
Abstract

Quinidine Sulfate as an antiarrhythmic drug has been used in the treatment of atrial fibrillation. Quinidine sulfate has both direct and indirect effects on cardiac rhythmicity. The direct effect of quinidine is to prolong the effective refractory period of the atrial and ventricular muscles with...

Author(s)
Sarchahi, A. A.; Rezakhani, A.; Saiedi, F.
Publisher
Shiraz University Press, Shiraz, Iran
Citation
Iranian Journal of Veterinary Research, 2004, 5, 1(Ser.No.9), pp 157-162
Abstract

Previous studies have indicated that intestinal P-glycoprotein (P-gp) limits the oral bioavailability of substrate drugs and alters systemic pharmacokinetics. In this study, dogs lacking functional P-gp were used to determine the contribution of P-gp to the oral bioavailability and systemic...

Author(s)
Mealey, K. L.; Waiting, D.; Raunig, D. L.; Schmidt, K. R.; Nelson, F. R.
Publisher
Blackwell Publishing Ltd, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2010, 33, 5, pp 453-460
AbstractFull Text

Author(s)
Petchdee, S.
Publisher
Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand
Citation
Thai Journal of Veterinary Medicine, 2017, 47, Supplement, pp S43
AbstractFull Text

Author(s)
Spier, A. W.
Publisher
North American Veterinary Community (NAVC), Gainesville, USA
Citation
Proceedings of the NAVC Conference, 18-22 January 2014, Orlando, Florida, USA. Volume 28, Small Animal & Exotics, 2014, pp unpaginated
Abstract

We investigated the effect of dexamethasone (DEX) at clinical doses on the pharmacokinetics of quinidine (QN) in dogs. Dogs (5 healthy 1-year-old male beagles) were orally administered DEX once daily for 5 days at 2.5 or 7.5 mg/day. QN (2 mg/kg) was intravenously injected 3 weeks before and one day ...

Author(s)
Zhang KeWei; Kohno, S.; Kuroha, M.; Kokue, E.; Shimoda, M.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2006, 68, 9, pp 903-907

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